|
|
| Product Name: | RSV604 | | Synonyms: | RSV604;CS-2092;Urea, N-[(3S)-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(2-fluorophenyl)-;(S)-1-(2-fluoro-phenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-urea;RSV604;RSV 604;virus,Respiratory syncytial virus,A 60444,respiratory,protein,inhibit,RSV,syncytial,A-60444,Inhibitor,A60444,RSV604,RSV 604,nucleocapsid,RSV-604 | | CAS: | 676128-63-5 | | MF: | C22H17FN4O2 | | MW: | 388.39 | | EINECS: | | | Product Categories: | | | Mol File: | 676128-63-5.mol |  |
| | RSV604 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:20): 0.04 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml | | form | A solid |
| | RSV604 Usage And Synthesis |
| Biological Activity | RSV604 (A-60444), a novel benzodiazepine, is an inhibitor of respiratory syncytial virus (RSV) with EC50 of 0.86 μM. It has the potential to treat RSV-related diseases. Phase 2. | | in vitro | RSV604 (5 days) inhibits the growth of four laboratory strains of RSV (RSS, Long, A2 and B), with EC 50 s ranging from 0.5 to 0.9 μM in plaque reduction assay.
It (6 days) inhibits RSV-induced HEp-2 cell death, with an EC 50 of 0.86 μM.
Also RSV604 (3 days) reduces viral antigen synthesis in RSV-infected HEp-2 cells, with an EC 50 of 1.7 μM.
RSV604 (1-20 μM; 7 days) dose-dependently inhibits RSV infection in human airway epithelial (HAE) cells, with no gross cytotoxicity, leakage of basolateral fluid to the apical surface, or alteration of cilium beat frequency. | | target | | Target | Value | RSV
(Cell-free assay) | 0.86 μM(EC50) |
|
| | RSV604 Preparation Products And Raw materials |
|