- CB1 antagonist 4
-
- $98.00 / 5mg
-
2025-11-10
- CAS:1253641-65-4
- Min. Order:
- Purity: 98.97%
- Supply Ability: 10g
- TM-38837
-
- $8.00 / 1kg
-
2025-09-25
- CAS:1253641-65-4
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
|
| | TM38837 Basic information |
| Product Name: | TM38837 | | Synonyms: | TM38837;peripheral,Cannabinoid Receptor,TM-38837,CB1,antiobesity,TM38837,inhibit,fat,TM 38837,Inhibitor,metabolic,fear;1H-Pyrazole-3-carboxamide, 1-(2,4-dichlorophenyl)-4-ethyl-N-1-piperidinyl-5-[5-[2-[4-(trifluoromethyl)phenyl]ethynyl]-2-thienyl]-;CB1 antagonist 4;TM38837, 10 mM in DMSO | | CAS: | 1253641-65-4 | | MF: | C30H25Cl2F3N4OS | | MW: | 617.51 | | EINECS: | | | Product Categories: | | | Mol File: | 1253641-65-4.mol |  |
| | TM38837 Chemical Properties |
| Melting point | 171-172 °C | | density | 1.38±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 41.67 mg/mL (67.48 mM) | | pka | 11.17±0.20(Predicted) | | form | Solid | | color | Off-white to light yellow |
| | TM38837 Usage And Synthesis |
| Uses | CB1 antagonist 4 (compound 8) is a peripheral selective cannabinoid receptor type 1 (CB1) receptor antagonist. CB1 antagonist 4 shows limited penetrance to the brain in order to minimize or prevent CNS adverse reactions, and preserves potential antiobesity effects. CB1 antagonist 4 reduces propensity for psychiatric side effects[1][2]. | | Biological Activity | TM38837 is a peripherally selective cannabinoid receptor type 1 (CB1) receptor antagonist. It has limited brain penetration to minimize or prevent CNS adverse effects and retain potential anti-obesity effects. Also it can reduces the propensity for psychotic side effects. | | in vivo | TM38837 (10-100 mg/kg; po) induces a significant increase in freezing behavior at 100 mg/kg. | Animal Model: | < td class="col2"> 7-8 weeks old male C57BL/6 N mice (B6N) | Dosage: | 10, 30, or 100 mg/kg | | Administration: | po < /td> | | Result: | High dose (100 mg/kg) induced a significant increase in freezing behavior. < /td> | | | target | | | IC 50 | CB1 | | storage | Store at -20°C | | References | [1] Micale V, et al. The Cannabinoid CB1 Antagonist TM38837 With Limited Penetrance to the Brain Shows ReducedFear-Promoting Effects in Mice. Front Pharmacol. 2019 Mar 20;10:207. DOI:10.3389/fphar.2019.00207
[2] Klumpers LE, et al. Peripheral selectivity of the novel cannabinoid receptor antagonist TM38837 in healthy subjects. Br J Clin Pharmacol. 2013 Dec;76(6):846-57. DOI:10.1111/bcp.12141 |
| | TM38837 Preparation Products And Raw materials |
|