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Tosylmethyl isocyanide

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Products Intro: Product Name:Tosylmethyl isocyanide
CAS:36635-61-7
Purity:99%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
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CAS:36635-61-7
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CAS:36635-61-7
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CAS:36635-61-7
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Lastest Price from Tosylmethyl isocyanide manufacturers

  • Tosylmethyl isocyanide
  • US $15.00-10.00 / KG
  • 2021-07-13
  • CAS:36635-61-7
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
  • Tosylmethyl isocyanide
  • US $15.00-10.00 / KG
  • 2021-07-09
  • CAS:36635-61-7
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
  • Tosylmethyl isocyanide
  • US $1.00 / PCS
  • 2021-06-02
  • CAS:36635-61-7
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 10 mt

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Tosylmethyl isocyanide Basic information
Product Name:Tosylmethyl isocyanide
Synonyms:1-[(isocyanomethyl)sulfonyl]-4-methyl-benzen;Tosylmethy isocyanide ,98%;Tosylmethyl isocyani;Isocyanomethyl 4-methylphenyl sulphone;Toluenesulfonyl Methyl isocyanide;4-[(Isocyanomethyl)sulphonyl]toluene, (Toluene-4-sulphonyl)methyl isocyanide;(p-Toluensulfonyl)methylisocyanide;(p-Tolylsulfonyl)methyl isocyanide, TosMIC, Tosylmethyl isocyanide
CAS:36635-61-7
MF:C9H9NO2S
MW:195.24
EINECS:253-140-1
Product Categories:cyanide;Building Blocks;Chemical Synthesis;Isocyanides;Nitrogen Compounds;Organic Building Blocks;Benzene derivatives;Boron, Nitrile, Thio,& TM-Cpds;Aliphatics;Sulfur Compounds (for Synthesis);Synthetic Organic Chemistry;Tosmic;Tesaglitazar Carbjdopa
Mol File:36635-61-7.mol
Tosylmethyl isocyanide Structure
Tosylmethyl isocyanide Chemical Properties
Melting point 109-113 °C(lit.)
density 1.2721 (rough estimate)
refractive index 1.5270 (estimate)
storage temp. 2-8°C
solubility water: slightly soluble
form Liquid
color Clear
Water Solubility insoluble
Sensitive Moisture Sensitive
Merck 14,9556
BRN 3592382
InChIKeyBBNNLJMGPASZPD-UHFFFAOYSA-N
CAS DataBase Reference36635-61-7(CAS DataBase Reference)
Safety Information
Hazard Codes T,Xi
Risk Statements 23/24/25
Safety Statements 36/37-45-38-36/37/39-28A
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
21
Hazard Note Irritant
HazardClass 6.1(b)
PackingGroup III
HS Code 29299000
MSDS Information
ProviderLanguage
(p-Tolylsulfonyl)methyl isocyanide English
SigmaAldrich English
ACROS English
ALFA English
Tosylmethyl isocyanide Usage And Synthesis
Chemical PropertiesPale yellow to light brown crystalline powder
UsesReagent for use in the preparation of biologically active pyrroles and imidazoles.1,2
UsesTosylmethyl Isocyanide is used as a synthetic reagent in the preparation of variety or biologically active heterocycles such as pyrroles and imidazoles. Tosylmethyl Isocyanide is reported to inhibit [ Fe]-hydrogenase with very high affinity.
UsesVersatile synthon in organic chemistry, especially in the synthesis of heterocyclic Compounds.
PreparationN-(p-Tolylsulfonylmethyl)formamide 1609:

A 3-L, three-necked, round-bottomed flask, equipped with a mechanical stirrer, a condenser, and a thermometer, was charged with sodium p-toluenesulfinate 1606 (267 g, 1.5 mol). After the addition of water (750 mL), a 34–37% solution of formaldehyde 1607 (350 mL, 378 g, ca. 4.4 mol), formamide 1608 (600 mL, 680 g, 15 mol), and formic acid (200 mL, 244 g, 5.3 mol), the stirred reaction mixture was heated at 90 C°. The sodium p-toluenesulfinate dissolved during the heating, and the clear solution was kept at 90–95 C° for 2 h. It was then cooled in an ice/salt bath with continued stirring and further cooled overnight in a freezer at 20 C°. The white solid produced was collected by suction filtration. It was washed thoroughly in a beaker by stirring with three 250 mL portions of iced water. The product was dried under reduced pressure over phosphorus pentoxide at 70 C° to provide 134–150 g (42–47%) of crude N-(p-tolylsulfonylmethyl)formamide 1609; mp 106–110 C°. This product was sufficiently pure to be used directly in the following reaction.
Purification MethodsUse an efficient fume cupboard. Purify TOSMIC by dissolving (50g) in CH2Cl2 (150mL) and passing it through a column (40x3cm) containing neutral alumina (100g) in CH2Cl2 and eluting with CH2Cl2. A nearly colourless solution (700mL) is collected, evaporated in vacuo and the residue (42-47g) of TOSMIC (m 113-114o dec) is recrystallised once from MeOH (m 116-117o dec). [Hoogenboom et al. Org Synth 57 102 1977, Lensen Tetrahedron Lett 2367 1972.] It also crystallises from EtOH (charcoal) [Saito & Itano, J Chem Soc, Perkin Trans 1 1 1986].
Tosylmethyl isocyanide Preparation Products And Raw materials
Preparation ProductsMETHYL-2-CHLOROOXAZOLE-5-CARBOXYLATE-->3-(3,4-DIHYDROXYPHENYL)PROPIONIC ACID
Tag:Tosylmethyl isocyanide(36635-61-7) Related Product Information
4-CHLOROBENZOYLACETONITRILE 1-ETHYL-1-TOSYLMETHYL ISOCYANIDE 1-CYCLOHEXYL-1-TOSYLMETHYL ISOCYANIDE 1-CYCLOBUTYL-1-TOSYLMETHYL ISOCYANIDE 1-BENZYL-1-TOSYLMETHYL ISOCYANIDE 1-(3,4-DIMETHOXYPHENYL)-1-TOSYLMETHYL ISOCYANIDE 1-PYRROL-2-YL-1-TOSYLMETHYL ISOCYANIDE 1-CYCLOPENTYL-1-TOSYLMETHYL ISOCYANIDE 1-N-PROPYL-1-TOSYLMETHYL ISOCYANIDE 1-(2,5-DICHLOROPHENYL)-1-TOSYLMETHYL ISOCYANIDE 1-ISOPROPYL-1-TOSYLMETHYL ISOCYANIDE 1-(2,6-DICHLOROPHENYL)-1-TOSYLMETHYL ISOCYANIDE 1-METHYL-1-TOSYLMETHYL ISOCYANIDE 1-(3,4-DICHLOROPHENYL)-1-TOSYLMETHYL ISOCYANIDE N-P-TOSYLGLYCINE SULFORHODAMINE B Tosyl cyanide p-Tolunitrile