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| | NSC5844 Basic information |
| Product Name: | NSC5844 | | Synonyms: | NSC5844;N,N'-bis(7-chloroquinolin-4-yl)ethane-1,2-diamine;1,2-Ethanediamine, N1,N2-bis(7-chloro-4-quinolinyl)-;RE-640;RE640;RE 640;NSC 5844; NSC-5844; RE 640; RE-640; RE640;NSC5844 (RE640) | | CAS: | 140926-75-6 | | MF: | C20H16Cl2N4 | | MW: | 383.27 | | EINECS: | | | Product Categories: | | | Mol File: | 140926-75-6.mol |  |
| | NSC5844 Chemical Properties |
| Boiling point | 632.6±55.0 °C(Predicted) | | density | 1.431±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 0.33 mg/ml; DMSO: 0.25 mg/ml; Ethanol: slightly soluble | | form | A crystalline solid | | pka | 6.61±0.50(Predicted) |
| | NSC5844 Usage And Synthesis |
| Description | NSC 5844 is a bis-quinoline with diverse biological activities. It inhibits the growth of P. falciparum strains that are sensitive (D-6) and resistant (W-2) to chloroquine in vitro (IC50s = 17 and 27 nM, respectively) but lacks activity against P. berghei in vivo. NSC 5844 inhibits the growth of MDA-MB-468 and MCF-7 breast cancer cells with GI50 values of 7.35 and 14.80 μM, respectively. It also inhibits 24% of botulinum neurotoxin serotype A light chain (BoNT/A LC) metalloprotease activity at a concentration of 20 μM. | | Uses | N1,N2-Bis(7-chloroquinolin-4-yl)ethane-1,2-diamine and other bisquinoline derivatives have potentials against chloroquine-resistant malaria. A useful intermediate for the preparation of other antimalarial bisaminoquinlines. |
| | NSC5844 Preparation Products And Raw materials |
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