(1S,2R)-N1-(3,4-二氯苯基)环己烷-1,2-二甲酰胺
中文名称 | (1S,2R)-N1-(3,4-二氯苯基)环己烷-1,2-二甲酰胺 |
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中文同义词 | (1S,2R)-N1-(3,4-二氯苯基)环己烷-1,2-二酰胺;化合物LU AF21934;(1S,2R)-N1-(3,4-二氯苯基)环己烷-1,2-二甲酰胺 |
英文名称 | Lu AF21934 |
英文同义词 | Lu AF21934;CS-2215;LU AF-21934;LU AF 21934;LU-AF21934;LU-AF-21934;2-PYRIMIDINAMINE,4-METHYL-N-[5-METHYL-4-(1H-PYRAZOL-4-YL)-2-THIAZOLYL]-, >98%;LuAF21934, >98%;LU-AF 21934;LU AF 21934;(1S,2R)-N1-(3,4-Dichlorophenyl)-1,2-cyclohexanedicarboxamide;1,2-Cyclohexanedicarboxamide, N1-(3,4-dichlorophenyl)-, (1S,2R)- |
CAS号 | 1445605-23-1 |
分子式 | C14H16Cl2N2O2 |
分子量 | 315.2 |
EINECS号 | |
相关类别 | |
Mol文件 | 1445605-23-1.mol |
结构式 |
(1S,2R)-N1-(3,4-二氯苯基)环己烷-1,2-二甲酰胺 性质
沸点 | 577.6±50.0 °C(Predicted) |
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密度 | 1.386±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | DMSO 中≥31.5 mg/mL;不溶于水; ≥5.03 mg/mL,乙醇溶液,超声波 |
形态 | 固体 |
酸度系数(pKa) | 13.23±0.70(Predicted) |
颜色 | 白色至米白色 |
mGlu4 Receptor 500 nM (EC 50 ) |
Lu AF21934 treatment shows a dose-dependent anxiolytic-like effect in the stress-induced hyperthermia, four-plate, and marble-burying tests. The anti-hyperthermic effect of Lu AF21934 (5 mg/kg) in the SIH test is inhibited by the benzodiazepine receptor antagonist flumazenil (10 mg/kg) and is not serotonin dependent. Lu AF21934 does not produce antidepressant-like effects in the tail suspension test in mice; however, it decreases the basal locomotor activity of mice that are not habituated to activity cages. Lu AF21934 (0.5-5 mg/kg sc) does not influence tremor but at doses of 0.5 and 2.5 mg/kg reverses harmaline-induced hyperactivity. Lu AF21934 at a dose of 2.5 mg/kg potentiates the inhibitory influence of harmaline on the exploratory activity and AP1 during the first 30 min of the measurement and counteracts the harmaline-increased basic activity during the period of 30-90 min. Lu AF21934 (0.1-5 mg/kg) dose-dependently inhibits hyperactivity induced by MK-801 or amphetamine. It also antagonizes head twitches and increases frequency of spontaneous excitatory postsynaptic currents in brain slices, induced by DOI.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-100366 | (1S,2R)-N1-(3,4-二氯苯基)环己烷-1,2-二甲酰胺 Lu AF21934 | 1445605-23-1 | 5mg | 850元 |
2024/08/19 | HY-100366 | (1S,2R)-N1-(3,4-二氯苯基)环己烷-1,2-二甲酰胺 Lu AF21934 | 1445605-23-1 | 10mM * 1mLin DMSO | 935元 |