| Company Name: |
MedBioPharmaceutical Technology Inc
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| Tel: |
021-69568360 18916172912 |
| Email: |
order@med-bio.cn |
| Products Intro: |
Product Name:Sp-Cyclic AMPS (sodium salt)
CAS:142439-95-0
Purity:98% Package:5mg; 1mg Remarks:Medbio
|
| Company Name: |
Beijing Jin Ming Biotechnology Co., Ltd.
|
| Tel: |
010-60605840 |
| Email: |
psaitong@jm-bio.com |
| Products Intro: |
Product Name:Sp-cAMPS sodium salt
CAS:142439-95-0
Purity:98% Package:5mg;10mg;25mg;50mg;100mg
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:Sp-Cyclic AMPS (sodium salt)
CAS:142439-95-0
Purity:98% Package:25 mg；50 mg
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:Sp-Cyclic AMPS (sodium salt)
CAS:142439-95-0
Purity:98% Package:1mg;5mg
|
|
| | Sp-Cyclic AMPS (sodium salt) Basic information |
| | Sp-Cyclic AMPS (sodium salt) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | ≤25mg/ml in H2O | | form | crystalline solid |
| | Sp-Cyclic AMPS (sodium salt) Usage And Synthesis |
| Description | Several cyclic nucleotide phosphodiesterases (PDE2, -5, -6, -10, and -11) contain a tandem of GAF domains in their N-terminal regulatory region that are thought to mediate cAMP- or cGMP-induced stimulation of adenylyl and guanylyl cyclases. Sp-cyclic AMPS (Sp-cAMPS) is a derivative of cAMP that binds the PDE10 GAF domain (EC50 = 40 μM). It has been used to study GAF-mediated stimulation of PDE10. | | references | [1] dostmann w r, taylor s s, genieser h g, et al. probing the cyclic nucleotide binding sites of camp-dependent protein kinases i and ii with analogs of adenosine 3', 5'-cyclic phosphorothioates[j]. journal of biological chemistry, 1990, 265(18): 10484-10491.
[2] hanks s k, quinn a m, hunter t. the protein kinase family: conserved features and deduced phylogeny of the catalytic domains[j]. science, 1988, 241(4861): 42-52.
[3] spicuzza l, belvisi m g, birrell m a, et al. evidence that the anti‐spasmogenic effect of the β‐adrenoceptor agonist, isoprenaline, on guinea‐pig trachealis is not mediated by cyclic amp‐dependent protein kinase[j]. british journal of pharmacology, 2001, 133(8): 1201-1212. |
| | Sp-Cyclic AMPS (sodium salt) Preparation Products And Raw materials |
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