- 2-Deoxy-D-ribose
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- $0.00 / 1Kg
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2024-04-09
- CAS:533-67-5
- Min. Order: 1Kg
- Purity: 99.9%
- Supply Ability: 200tons
- 2-Deoxy-D-ribose
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- $307.20 / 25Kg/Drum
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2023-11-13
- CAS:533-67-5
- Min. Order: 1Kg/Bag
- Purity: 98%
- Supply Ability: 10tons
- 2-Deoxy-D-ribose
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- $40.00 / 1kg
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2023-09-08
- CAS:533-67-5
- Min. Order: 1kg
- Purity: 0.99
- Supply Ability: 10 tons
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| | 2-Deoxy-D-ribose Basic information |
| | 2-Deoxy-D-ribose Chemical Properties |
| Melting point | 89-90 °C(lit.) | | Boiling point | 167.23°C (rough estimate) | | alpha | -57 º (c=1, H2O, 24hr) | | density | 1.0590 (rough estimate) | | refractive index | -56 ° (C=1, H2O) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated) | | form | Crystalline Powder | | pka | 12.61(at 25℃) | | color | White to slightly yellow | | optical activity | [α]22/D 59°, c = 1 in H2O | | Water Solubility | soluble | | Sensitive | Hygroscopic | | Merck | 14,2908 | | BRN | 1721978 | | Stability: | Hygroscopic | | InChIKey | ASJSAQIRZKANQN-CRCLSJGQSA-N | | CAS DataBase Reference | 533-67-5(CAS DataBase Reference) | | NIST Chemistry Reference | D-Erythro-pentose, 2-deoxy-(533-67-5) | | EPA Substance Registry System | D-erythro-Pentose, 2-deoxy- (533-67-5) |
| | 2-Deoxy-D-ribose Usage And Synthesis |
| Description | 2-deoxy-D-Ribose is a reducing sugar formed as a degradation product during metabolism of thymidine by thymidine phosphorylase. It increases levels of reactive oxygen species (ROS) in HL-60 human leukemia cells when used at a concentration of 15 mM. 2-deoxy-D-Ribose (10 μM) induces tubulogenesis and migration of bovine aortic endothelial (BAE) cells. Topical administration of 2-deoxy-D-ribose increases blood vessel formation and accelerates wound healing in a rat full-thickness cutaneous wound model. | | Chemical Properties | White powder | | Uses | 2-Deoxy-D-ribose is used as a precursor to deoxyribonucleic acid. It induces apoptosis by inhibiting the synthesis and increasing the efflux of glutathione. Further, it is used in the synthesis of optically active dipyrrolyl alkanols from pyrroles on the surface of montmorillonite KSF clay. | | Definition | ChEBI: 2-deoxy-D-ribose is a deoxypentose that is D-ribose in which the hydroxy group at position C-2 is replaced by hydrogen. It has a role as a human metabolite, a Saccharomyces cerevisiae metabolite and a mouse metabolite. It is functionally related to a D-ribose. | | Purification Methods | Dissolve 2-deoxy--D-ribose in a little H2O, evaporate to a syrup (in a vacuum), and seed to crystallise. Triturate the crystals with a little EtOAc containing 5% MeOH, decant and dry in vacuum over P2O5. It is best purified via the anilide which separates from a mixture of the ribose (100-125g) in MeOH (100mL) and redistilled aniline (40mL) in a few minutes. After standing for 20hours at room temperature, it is cooled to 0o, filtered, washed with 50% aqueous MeOH and Et2O followed by recrystallisation from ethylene glycol monomethyl ether. The anilide has m 172-173o, [ ] D 25 +46o (equilibrium in pyridine). The anilide (5g), benzaldehyde (5mL) and benzoic acid (0.5g) in H2O (150mL) are shaken mechanically for 2024hours. The aqueous phase is extracted with Et2O (3x), decolourised with a little charcoal and evaporated in a vacuum to a syrup. This is dried over P2O5 in high vacuum. The syrupy sugar weighs 3.1g and crystallises in a few days, but more rapidly on seeding. Triturate it with a little EtOAc containing 5% MeOH, decant and dry it over P2O5. At this stage it has m 78-82o, [ ] D 25 -57o (c 1, H2O final). This is a mixture of and anomers. Pure -anomer is obtained by recrystallisation from EtOAc The -anomer when recrystallised from EtOAc and isoPrOH has m 96-98o, [ ] D 25 -55o (c 0.5, H2O final). [Sowden Biochemical Preparations 5 75 1957.] The mutarotation is as follows: [] D 20.5 +96.3o(0minutes), -76o(33minutes), -56o (24hours) (c 5.8 MeOH). It is moderately hygroscopic and should be kept in a well stoppered bottle. It also crystallises from diethyl ether. [Deriaz et al. J Chem Soc 1879 1949, Beilstein 1 IV 4181, Hauske & Rapoport J Org Chem 4 4 2472 1979.] |
| | 2-Deoxy-D-ribose Preparation Products And Raw materials |
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