- CONDURITOL B EPOXIDE
-
- $0.00 / 1KG
-
2022-09-12
- CAS:6090-95-5
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1ton
|
| | CONDURITOL B EPOXIDE Basic information |
| Product Name: | CONDURITOL B EPOXIDE | | Synonyms: | conduritolepoxide;(+/-) CONDURITOL B EPOXIDE;CONDURITOL B EPOXIDE;DL-1,2-ANHYDRO-MYO-INOSITOL;1,2-Anhydro-myo-inositol;(1R,2R,3S,4S,5R,6S)-7-oxabicyclo[4.1.0]heptane-2,3,4,5-tetrol;myo-Inositol, 1,2-anhydro- (9CI);4h-3,1-benzoxazin-4-one, 5-methyl-2-(3-nitrophenyl)- | | CAS: | 6090-95-5 | | MF: | C6H10O5 | | MW: | 162.14 | | EINECS: | | | Product Categories: | EPOXYDE;All Inhibitors;Glycosidase Inhibitors;Inhibitors;api | | Mol File: | 6090-95-5.mol |  |
| | CONDURITOL B EPOXIDE Chemical Properties |
| Melting point | 157-159 | | Boiling point | 360.5±42.0 °C(Predicted) | | density | 1.925±0.06 g/cm3 (20 ºC 760 Torr) | | storage temp. | 2-8°C | | solubility | Soluble in Water (up to 25 mg/ml) or in DMSO | | pka | 13.08±0.70(Predicted) | | form | White solid | | color | White | | Stability: | Moisture Sensitive |
| WGK Germany | 3 | | Hazard Note | Harmful | | HS Code | 2932990090 |
| | CONDURITOL B EPOXIDE Usage And Synthesis |
| Description | Conduritol B epoxide (6090-95-5) is a β-Glycosidase inhibitor.1,2 May be used for generation of the “Gaucher mouse”3 and the in vitro model of the Gaucher cell4. | | Chemical Properties | White Crystalline Solid | | Uses | inhibitor of glucosidases | | Definition | ChEBI: 1-D-1,2-anhydro-myo-inositol is a conduritol epoxide resulting from the formal epoxidation of the double bond of (+)-conduritol B. It has a role as an EC 3.2.1.48 (sucrose alpha-glucosidase) inhibitor and an EC 3.2.1.10 (oligo-1,6-glucosidase) inhibitor. It is functionally related to a (+)-conduritol B. It is an enantiomer of a 1-L-1,2-anhydro-myo-inositol. | | General Description | Conduritol B epoxide?(CBE) is a mix of 1-L-1,2-anhydro-myo-inositol and 1-D-1,2-anhydro-myo-inositol. | | Biochem/physiol Actions | Conduritol B epoxide?(CBE)?is capable of inactivating sucrase-isomaltase irreversibly. It can be used to produce cell and animal models to study on Gaucher disease (GD) and Parkinson′s disease (PD). | | storage | Store at -20°C | | References | 1) Datta and Radin (1988), Normalization of liver glucosylceramide levels in the “Gaucher” mouse by phosphatidylserine injection;? Biochem. Biophys. Res. Commun., 152 155
2) Radin and Vunnam (1981), Inhibitors of cerebroside metabolism;? Methods Enzymol., 72 673
3) Stephens et al. (1981), Distribution of conduritol B epoxide in the animal model for gaucher’s disease (Gaucher mouse); Biochim. Biophys. Acta, 672 29
4) Newburg et al. (1986), beta-Glucosidase inhibition in murine peritoneal macrophages by conduritol-B-epoxide: an in vitro model of the Gaucher cell;? Biochim. Biophys. Acta, 877 121 |
| | CONDURITOL B EPOXIDE Preparation Products And Raw materials |
|