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| | CP671305 Basic information |
| Product Name: | CP671305 | | Synonyms: | CP671305;CP-671305; CP 671305; CP671305; UNII-9LH034R9R9;445295-04-5;UNII-9LH034R9R9;CS-2886;Propanoic acid, 2-[4-[[[[2-(1,3-benzodioxol-5-yloxy)-3-pyridinyl]carbonyl]amino]methyl]-3-fluorophenoxy]-, (2R)-;(R)-2-(4-((2-(benzo[d][1,3]dioxol-5-yloxy)nicotinamido)methyl)-3-fluorophenoxy)propanoic acid;CP 671305,Inhibitor,Phosphodiesterase (PDE),CP671305,CP-671305,inhibit | | CAS: | 445295-04-5 | | MF: | C23H19FN2O7 | | MW: | 454.4 | | EINECS: | | | Product Categories: | API | | Mol File: | 445295-04-5.mol |  |
| | CP671305 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 50 mg/ml; DMSO: 25 mg/ml; Ethanol: 3 mg/ml; PBS (pH 7.2): 2 mg/ml | | form | A crystalline solid |
| | CP671305 Usage And Synthesis |
| Description | CP 671,305 is a potent inhibitor of phosphodiesterase 4D (PDE4D; IC50 = 3 nM). It is selective for PDE4D over PDE4A, -B, and -C (IC50s = 310, 287, and 3,858 nM, respectively), as well as over PDE1-3 and 5 (IC50s = >5,000 nM for all). CP 671,305 inhibits release of leukotriene E4 (LTE4; ) from eosinophils (IC50 = 52 nM) and LTB4 from neutrophils (IC50 = 106 nM). In vivo, CP 671,305 inhibits antigen-induced pulmonary eosinophil influx in cynomolgus monkeys in a dose-dependent manner. |
| | CP671305 Preparation Products And Raw materials |
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