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| | Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate Basic information |
| | Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate Chemical Properties |
| Melting point | 100 °C | | storage temp. | -20°C | | solubility | DMF: 0.4 g/mL, clear | | form | Powder | | color | White to off-white | | Water Solubility | moderately soluble | | Sensitive | Moisture Sensitive | | BRN | 7845702 | | Stability: | Moisture Sensitive | | InChIKey | CYKRMWNZYOIJCH-UHFFFAOYSA-N | | CAS DataBase Reference | 132705-51-2(CAS DataBase Reference) |
| | Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate Usage And Synthesis |
| Chemical Properties | white to off-white powder | | Uses | It can be used as a coupling reagent:
- For Suzuki–Miyaura cross-coupling of phenols and arylboronic acids to synthesize biaryls and heterobiaryls.
- To functionalize pyrimidines (synthesized from 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) via the Kappe dehydrogenation) by using various nucleophiles.
- To synthesize formamidines by coupling with various primary amines and N,N-diisopropylethylamine.
It can also be used as an activating reagent:
- For the activation of C-OH bond in tautomerizable heterocycles to form the phosphonium salt which aids the Sonogashira coupling of heterocycles with various alkynes.
- For the one–pot activation of C-O bond in phenols and further coupling reaction with phosphine oxide or phosphite to form C-P bonds.
| | Uses | A stable reagent for the coupling of N-Methylamino acids in peptide synthesis. |
| | Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate Preparation Products And Raw materials |
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