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7-Ethyl-10-hydroxycamptothecin

7-Ethyl-10-hydroxycamptothecin Suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: +86 (0)571-855 867 18
Email: sales@capotchem.com
Products Intro: Product Name:7-Ethyl-10-hydroxycamptothecin
CAS:86639-52-3
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:7-Ethyl-10-hydroxycamptothecin
CAS:86639-52-3
Purity:99% Package:100g,500g,1kg,5kg,10kg
Company Name: Beijing Cooperate Pharmaceutical Co.,Ltd.
Tel: +86-10-60279497 +86(0)15646567669
Email: sales01@cooperate-pharm.com
Products Intro: Product Name:7-Ethyl-10-hydroxycamptothecin
CAS:86639-52-3
Purity:98% Package:100G;1KG;50KG;100KG;1000KG
Company Name: Shanghai Bojing Chemical Co.,Ltd.
Tel: +86-21-37122233
Email: Candy@bj-chem.com
Products Intro: Product Name:7-Ethyl-10-hydroxycamptothecin
CAS:86639-52-3
Purity:99% Package:1kg;25kg;200kg Cardboard barrels Remarks:White powder
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:86639-52-3
Purity:99% Package:500G;1KG;5KG;25KG

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7-Ethyl-10-hydroxycamptothecin Basic information
Product Name:7-Ethyl-10-hydroxycamptothecin
Synonyms:NK 012;7-etyl-10-hydroxycaMptothecin;7,11-Diethyl-10- hydroxy-caMptothecin;Ethyl-10-hydroxycaMptoth;11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;CaMptothecin 7-Ethyl-10-Hydroxy IMpurity;CAMPTOTHECIN, 7-ETHYL-10-HYDROXY;4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
CAS:86639-52-3
MF:C22H20N2O5
MW:392.4
EINECS:643-093-9
Product Categories:Antitumors for Research and Experimental Use;Biochemistry;Natural Plant Extract;Chiral Reagents;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Natural Anti-cancer Medical Materials and It's Derivatives;Pharmaceutical Raw Materials;Miscellaneous Natural Products;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Chiral Reagents, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;Inhibitors
Mol File:86639-52-3.mol
7-Ethyl-10-hydroxycamptothecin Structure
7-Ethyl-10-hydroxycamptothecin Chemical Properties
Melting point 217 °C
refractive index 21.5 ° (C=0.2, THF)
storage temp. −20°C
solubility DMSO: soluble1mg/mL
form powder
InChIKeyFJHBVJOVLFPMQE-QFIPXVFZSA-N
CAS DataBase Reference86639-52-3(CAS DataBase Reference)
Safety Information
Hazard Codes T
Risk Statements 25
Safety Statements 45
RIDADR 2811
WGK Germany 3
RTECS UQ0491000
HazardClass 6.1
PackingGroup 
HS Code 29399990
MSDS Information
7-Ethyl-10-hydroxycamptothecin Usage And Synthesis
Chemical PropertiesLight-Yellow Solid
UsesA metabolite of Irinotecan, a DNA topoisomerase inhibitor
DefinitionChEBI: A member of the class of pyranoindolizinoquinolines that is (4S)-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione bearing two additional ethyl substituents at positions 4 and 11 as well as two additional hydroxy substitu nts at positions 4 and 9. It is the active metabolite of irinotecan and is ~1000 times more active than irinotecan itself.
Biological ActivityActive metabolite of CPT-11 that inhibits DNA topoisomerase I (IC 50 values are 0.74 and 1.9 μ M in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC 50 values are 0.077 and 1.3 μ M respectively) but does not affect protein synthesis. Displays potent antitumor activity against a range of human tumor cell lines (IC 50 values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively).
7-Ethyl-10-hydroxycamptothecin Preparation Products And Raw materials
Preparation ProductsIrinotecan
Tag:7-Ethyl-10-hydroxycamptothecin(86639-52-3) Related Product Information
7-ETHYL-10-HYDROXYCAMPTOTHECIN,98% (4R)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione 7-ethyl-10-hydroxycamptothecin beta-glucuronide Hydroxyl camptothecine Ethyl vanillin 1-Hydroxyethylidene-1,1-diphosphonic acid (+)-Camptothecin Diethyl ether Ethylbenzene Etanol 7-Ethyl-10-hydroxycamptothecin Ethyl propionate Camptothecin Series--10-hydroxycamptothecin Ethyl acetate Ethyl formate Ethyl acrylate Ethylparaben 10-HYDROXYCAMPTOTHECIN