|
|
| | Solasodine, hydrochloride Basic information |
| | Solasodine, hydrochloride Chemical Properties |
| Melting point | 288-290 °C | | storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere | | solubility | Methanol (Slightly, Heated) | | form | Solid | | color | White to Off-White |
| | Solasodine, hydrochloride Usage And Synthesis |
| Uses | Solasodine Hydrochloride enhances the effect of As2O3 in inducing apoptosis in HeLa cell, which is related to its inhibiting telomerase activity in HeLa cells. | | in vivo | Solasodine (25-100mg/kg; intraperitoneal injection; once) hydrochloride treatment significantly delays latency of hind limb tonic extensor (HLTE) phase in the PCT-induced convulsions. And significantly potentiates Thiopental-provoked sleep in a dose-dependent manner. Solasodine hydrochloride has anticonvulsant and CNS depressant activities[2].
Solasodine (375 μM; i.c.v.; for 2 weeks) hydrochloride treatment results a significant increase in bromodeoxyuridine uptake by cells of the ependymal layer, subventricular zone, and cortex that co-localized with doublecortin immunostaining. Solasodine hydrochloride treatment in rats results in a dramatic increase in expression of the cholesterol- and drug-binding translocator protein in ependymal cells[1]. | Animal Model: | Swiss albino mice (18-25g) treated with Picrotoxin (PCT) or Thiopental[2] | | Dosage: | 25 mg/kg, 50 mg/kg and 100mg/kg | | Administration: | Intraperitoneal injection; once | | Result: | Significantly delayed latency of hind limb tonic extensor (HLTE) phase in the PCT-induced convulsions. And significantly potentiated Thiopental-provoked sleep in a dose-dependent manner.
|
|
| | Solasodine, hydrochloride Preparation Products And Raw materials |
|