| Company Name: |
United States Biological
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| Tel: |
800.520.3011 or 781.639.5092 |
| Email: |
chemicals@usbio.net |
| Products Intro: |
Product Name:PD 158780
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| | PD 158780 Basic information |
| Product Name: | PD 158780 | | Synonyms: | 4-[(3-BROMOPHENYL)AMINO]-6-(METHYLAMINO)-PYRIDO[3,4-D]PYRIDIMINE;PD 158780 | | CAS: | | | MF: | C14H12BrN5 | | MW: | 330.18 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | PD 158780 Chemical Properties |
| | PD 158780 Usage And Synthesis |
| Uses | PD 158780 is a potent tyrosine kinase inhibitor of the epidermal growth factor receptor and has been shown to delay substantial growth of tumors in vivo tumor models. | | Enzyme inhibitor | This photosensitive pyridopyrimidine (FW = 330.19 g/mol), known systematically as 4-[(3-bromophenyl)amino]-6-(methylamino)pyrido[3,4- d]pyridimine, inhibits EPGFR (epidermal growth factor receptor) proteintyrosine kinase (IC50 = 8 pM). In addition, PD 158780 inhibits heregulinstimulated autophosphorylation in SK-BR-3 (IC50 = 49 nM) and MDA-MB- 453 (IC50 = 52 nM) breast carcinomas. |
| | PD 158780 Preparation Products And Raw materials |
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