886992-99-0
中文名称 | 886992-99-0 |
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中文同义词 | FAP抑制剂(AC-GLY-BOROPRO);化合物 T10227 |
英文名称 | Ac-Gly-BoroPro |
英文同义词 | Ac-Gly-BoroPro;Ac-Gly-BoroPro?, >98%;Boronic acid, B-[(2S)-1-[2-(acetylamino)acetyl]-2-pyrrolidinyl]-;AcGlyBoroPro,Ac Gly BoroPro |
CAS号 | 886992-99-0 |
分子式 | C8H15BN2O4 |
分子量 | 214.03 |
EINECS号 | |
相关类别 | 细胞生物学试剂 |
Mol文件 | 886992-99-0.mol |
结构式 |
886992-99-0 性质
密度 | 1.26±0.1 g/cm3(Predicted) |
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储存条件 | Store at -20°C,unstable in solution, ready to use. |
溶解度 | 二甲基亚砜:≥ 50 mg/mL(233.61 mM) |
酸度系数(pKa) | 9.72±0.20(Predicted) |
Ki: 23 nM (FAP)
FAP has been implicated in cancer; however, its specific role remains elusive because inhibitors that distinguish FAP from other prolyl peptidases like dipeptidyl peptidase-4 (DPP-4) have not been developed. Ac-Gly-BoroPro selectively inhibits FAP relative to other prolyl peptidases. FAP reacts readily with submicromolar concentrations of Ac-Gly-BoroPro, reaching steady state inhibition levels rapidly (K i =23±3 nM). In contrast, DPP-4 requires higher Ac-Gly-BoroPro concentrations for inhibition and a longer time to reach steady state inhibition levels (K i =377±18 nM). Ac-Gly-BoroPro inhibits other prolyl peptidases (DPP-7, DPP-8, DPP-9, prolyl oligopeptidase, and acylpeptide hydrolase) with K i values ranging from 9- to 5400-fold higher than that for FAP inhibition. The N-acyl-linkage in Ac-Gly-BoroPro blocks the N terminus of the inhibitor, making it less nucleophilic and therefore unlikely to cyclize.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/25 | HY-101801 | 886992-99-0 Ac-Gly-BoroPro | 886992-99-0 | 1mg | 2115元 |
2024/01/25 | HY-101801 | 886992-99-0 Ac-Gly-BoroPro | 886992-99-0 | 5mg | 8100元 |