NHBOC-PEG7-OH
| 中文名称 | NHBOC-PEG7-OH |
|---|---|
| 中文同义词 | 叔丁氧酰胺-七聚乙二醇;氨基叔丁酯-七聚乙二醇-羟基;叔丁氧羰基七聚乙二醇羟基;22-羟基-5,8,11,14,17,20-六氧杂-2-氮杂二十二酸叔丁酯;T-BUTYL 20-HYDROXY-3,6,9,12,15,18-HEXAOXAICOSYLCARBAMATE;叔丁氧羰基七聚乙二醇;(20-羟基-3,6,9,12,15,18-六氧杂二十烷基)氨基甲酸叔丁酯;氨基叔丁酯-七聚乙二醇 |
| 英文名称 | BocNH-PEG7-OH |
| 英文同义词 | BocNH-PEG7-OH;NHBoc-PEG7-OH;5,8,11,14,17,20-Hexaoxa-2-azadocosanoic acid, 22-hydroxy-, 1,1-dimethylethyl ester;t-boc-N-amido-PEG7-alcohol;t-butyl20-hydroxy-3,6,9,12,15,18-hexaoxaicosylcarbamate;tert-Butyl (20-hydroxy-3,6,9,12,15,18-hexaoxaicosyl)carbamate;20-(Boc-amino)-3,6,9,12,15,18-hexaoxa-1-icosanol;BocNH-PEG7-OH/5,8,11,14,17,20-Hexaoxa-2-azadocosanoic acid, 22-hydroxy-, 1,1-dimethylethyl ester |
| CAS号 | 1292268-13-3 |
| 分子式 | C19H39NO9 |
| 分子量 | 425.51 |
| EINECS号 | |
| 相关类别 | 其它;助剂 |
| Mol文件 | 1292268-13-3.mol |
| 结构式 |  |
NHBOC-PEG7-OH 性质
| 沸点 | 521.1±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.090±0.06 g/cm3(Predicted) |
| 溶解度 | 溶于水、DMSO、DCM、DMF |
| 酸度系数(pKa) | 12.23±0.46(Predicted) |
| 形态 | 液体 |
| 颜色 | 无色至浅黄 |
N-Boc-PEG7-alcohol 是一种 PROTAC 连接桥，属于 PEG 类和 Alkyl/ether 类。N-Boc-PEG7-alcohol 可用于合成一系列 PROTAC 分子。N-Boc-PEG7-alcohol 是一种可降解 (cleavable) 的 ADC 连接桥，用于抗体药物结合物 (ADCs) 的合成。
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Cleavable
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PEGs
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Alkyl/ether
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PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.