| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:AS2553627;AS2553627
CAS:1251906-10-1
Purity:98% Package:5 mg
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| | AS2553627 Basic information |
| Product Name: | AS2553627 | | Synonyms: | AS2553627;1-Piperidinepropanenitrile, 3-(dipyrrolo[2,3-b:2',3'-d]pyridin-1(6H)-yl)-4-methyl-β-oxo-, (3R,4R)- | | CAS: | 1251906-10-1 | | MF: | C18H19N5O | | MW: | 321.38 | | EINECS: | | | Product Categories: | | | Mol File: | 1251906-10-1.mol |  |
| | AS2553627 Chemical Properties |
| Boiling point | 666.3±55.0 °C(Predicted) | | density | 1.38±0.1 g/cm3(Predicted) | | pka | 6.12±0.60(Predicted) |
| | AS2553627 Usage And Synthesis |
| Description | AS2553627 is a novel JAK inhibitor. AS2553627 prevents chronic rejection in rat cardiac allografts. AS2553627 potently inhibited JAK kinases but showed no inhibition of other kinases, including TCR-associated molecules. In a rat cardiac transplant model, oral administration of AS2553627 alone or co-administration with a sub-therapeutic dose of tacrolimus effectively prolonged cardiac allograft survival, suggesting the efficacy in treating acute rejection. AS2553627 may be a therapeutic candidate for the prevention of not only acute but also chronic rejection in cardiac transplantation. |
| | AS2553627 Preparation Products And Raw materials |
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