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| | JNJ-42847922 Basic information |
| Product Name: | JNJ-42847922 | | Synonyms: | [2-(4,6-DIMETHYLPYRIMIDIN-2-YL)-1,3,3A,4,6,6A-HEXAHYDROPYRROLO[3,4-C]PYRROL-5-YL]-[2-FLUORO-6-(TRIAZOL-2-YL)PHENYL]METHANONE;JNJ-42847922;JNJ-42847922,Cid 67116280;[5-(4,6-dimethyl-pyrimidin-2-yl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-(2-fluoro-6-[1,2,3]triazol-2-yl-phenyl)-methanone;Methanone, [5-(4,6-dimethyl-2-pyrimidinyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl][2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl]-;Seltorexant (JNJ-42847922);Hypocretin Receptor,JNJ42847922,HCRT Receptor,Orexin Receptor (OX Receptor),Seltorexant,movement,barrier,insomnia,somnolence,eye,blood-brain,inhibit,rapid,selective,sleep,JNJ 42847922,Inhibitor | | CAS: | 1293281-49-8 | | MF: | C21H22FN7O | | MW: | 407.44 | | EINECS: | | | Product Categories: | API | | Mol File: | 1293281-49-8.mol |  |
| | JNJ-42847922 Chemical Properties |
| Boiling point | 667.7±65.0 °C(Predicted) | | density | 1.46±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 250 mg/mL (613.59 mM) | | pka | 6.50±0.50(Predicted) |
| | JNJ-42847922 Usage And Synthesis |
| Description | Seltorexant, also known as JNJ-42847922 and MIN-202, is a potent OX2R antagonist that has been shown to promote sleep in various species. JNJ-42847922 had an approximate 2-log selectivity ratio versus the human orexin-1 receptor. Ex vivo receptor binding studies demonstrated that JNJ-42847922 quickly occupied OX2R binding sites in the rat brain after oral administration and rapidly cleared from the brain. Seltorexant shows antidepressant and sleep-promoting effects in patients with major depressive disorder. JNJ-42847922 induces somnolence in healthy subjects without residual central effects. |
| | JNJ-42847922 Preparation Products And Raw materials |
| Raw materials | Benzoyl chloride, 2-fluoro-6-(2H-1,2,3-triazol-2-yl)--->Pyrrolo[3,4-c]pyrrole, 2-(4,6-dimethyl-2-pyrimidinyl)octahydro--->5-Benzyl-2-Boc-hexahydro-pyrrolo[3,4-C]pyrrole-->2-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid-->3-Benzyl-3,7-diazabicyclo[3.3.0]octane-->2-BOC-HEXAHYDRO-PYRROLO[3,4-C]PYRROLE-->2-FLUORO-6-IODOBENZOIC ACID |
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