| Company Name: |
Borenpharm Co., Ltd
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| Tel: |
027-65563561 |
| Email: |
sales@borenpharm.com |
| Products Intro: |
Product Name:2-(Azido-peg3-amido)-1,3-bis(carboxylethoxy)propane
CAS:2086689-05-4
Purity:95% HPLC Package:1g; 5g
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| | 2-(Azido-PEG3-amido)-1,3-bis(carboxylethoxy)propane Basic information |
| | 2-(Azido-PEG3-amido)-1,3-bis(carboxylethoxy)propane Chemical Properties |
| | 2-(Azido-PEG3-amido)-1,3-bis(carboxylethoxy)propane Usage And Synthesis |
| Description | 2-(Azido-PEG3-amido)-1,3-bis(carboxylethoxy)propane enable PEGylation via Click Chemistry. The terminal carboxylic acids can react with primary amino(NH2) groups in the presence of activator HATU or EDC. | | Uses | 2-Azido-PEG3-amido-13-biscarboxylethoxypropane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. 2-(Azido-PEG3-amido)-1,3-bis(carboxylethoxy)propane is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | 2-(Azido-PEG3-amido)-1,3-bis(carboxylethoxy)propane Preparation Products And Raw materials |
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