| Company Name: |
Shanghai Aladdin Bio-Chem Technology Co.,LTD
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| Tel: |
18521735133 18521732826; |
| Email: |
market@aladdin-e.com |
| Products Intro: |
Product Name:L-N6-(1-Iminoethyl)lysine dihydrochloride
CAS:159190-45-1
Purity:95% Package:10mg/RMB 441.90;250mg/RMB 3999.00;50mg/RMB 1029.90
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| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
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orderCN@merckgroup.com |
| Products Intro: |
Product Name:L-N6-(1-Iminoethyl)lysine
CAS:159190-45-1
Purity:>=97% (HPLC) Package:10mg Remarks:I8021
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| | L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE Basic information |
| Product Name: | L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE | | Synonyms: | L-NIL HCL;L-N6-(1-IMINOETHYL)-LYSINE 2HCL;L-N6-(1-IMINOETHYL)LYSINE, DIHCL;L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE;N6-(1-IMINOETHYL)-L-LYSINE DIHYDROCHLORIDE;L-Lysine, N6-(1-iMinoethyl)-, (Hydrochloride) (1:2);L-Lysine ω-acetamidine dihydrochloride;L-NIL DIHYDROCHLORIDE | | CAS: | 159190-45-1 | | MF: | C8H18ClN3O2 | | MW: | 223.7 | | EINECS: | | | Product Categories: | Nitric Oxide | | Mol File: | 159190-45-1.mol |  |
| | L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE Chemical Properties |
| storage temp. | -20°C | | solubility | DMF: 15 mg/mL; DMSO: 15 mg/mL; Ethanol: 1 mg/mL; PBS: 30 mg/mL; Water: 50 mg/ml | | form | White to off-white solid. |
| Provider | Language |
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ACROS
| English |
| | L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE Usage And Synthesis |
| Description | L-NIL is a relatively selective inhibitor of iNOS. It exhibits IC50 values of 0.4-3.3 μM for iNOS as opposed to 8-38 and 17-92 μM for eNOS and nNOS, respectively. L-NIL effectively inhibits iNOS both in vitro and in vivo. L-NIL has been used to demonstrate a critical role for iNOS in the immune response to infection by the protozoan L. major. | | Uses | L-N6-(1-Iminoethyl)lysine dihydrochloride has been used as an inducible nitric oxide synthase (iNOS) inhibitor:
- to study its effects on leptin-induced modulation of fibronectin type III domain-containing five (FNDC5)/irisin in myocytes and fat cells of murine
- to study its effects on leptin-induced inflammation in hepatocytes
- to block the production of nitric oxide in mice bone marrow mesenchymal stromal cells (BMSCs)
| | Definition | ChEBI: N(6)-acetimidoyl-L-lysine dihydrochloride is a hydrochloride salt prepared from N(6)-acetimidoyl-L-lysine and two equivalents of hydrogen chloride. A selective inhibitor of inducible nitric oxide synthase. It has a role as an EC 1.14.13.39 (nitric oxide synthase) inhibitor. It contains a N(6)-acetimidoyl-L-lysinium(2+). | | Biochem/physiol Actions | Selective inhibitor of inducible nitric oxide synthase (iNOS). |
| | L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE Preparation Products And Raw materials |
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