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Melatonine

Melatonine Suppliers list
Company Name: Jinan Jianfeng Chemical Co., Ltd
Tel: 15562555968
Email: info@pharmachemm.com
Products Intro: Product Name:Melatonine
CAS:73-31-4
Purity:99% Package:5KG;1KG Remarks:Pharm api
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: 86-0551-65418684 18949823763
Email: info@tnjchem.com
Products Intro: Product Name:Melatonine
CAS:73-31-4
Purity:99.9% Package:1KG;5USD
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: Product Name:73-31-4
CAS:73-31-4
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: Hubei XinRunde Chemical Co., Ltd.
Tel: +8615102730682; +8618874586545
Email: bruce@xrdchem.cn
Products Intro: Product Name:Melatonine
CAS:73-31-4
Purity:99% Package:100g/ bag, 2 kg/ bag, 25kg/ carton or as required Remarks:white to off white crystalline powder
Company Name: Nanjing Finetech Chemical Co., Ltd.
Tel: 025-85710122 17714198479
Email: sales@fine-chemtech.com
Products Intro: CAS:73-31-4
Purity:99%min Package:1KG;10KG;100KG;500KG;100g Remarks:ISO certified

Lastest Price from Melatonine manufacturers

  • Melatonine
  • US $10.00 / KG
  • 2019-12-02
  • CAS:73-31-4
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 10 mt
  • Melatonine
  • US $0.00 / mg
  • 2019-11-29
  • CAS:73-31-4
  • Min. Order: 5mg
  • Purity: ≥98%(HPLC)
  • Supply Ability: 10 g
  • Melatonin
  • US $0.00 / KG
  • 2019-11-01
  • CAS:73-31-4
  • Min. Order: 1g
  • Purity: 99.9%
  • Supply Ability: 1 ton
Melatonine Chemical Properties
Melting point 116.5-118 °C(lit.)
Boiling point 374.44°C (rough estimate)
density 1.1099 (rough estimate)
refractive index 1.6450 (estimate)
Fp 9℃
storage temp. -15°C
solubility Soluble in ethanol to at least 50mg/ml
pka16.26±0.46(Predicted)
form Powder
color white to off-white
Merck 14,5816
BRN 205542
InChIKeyDRLFMBDRBRZALE-UHFFFAOYSA-N
CAS DataBase Reference73-31-4(CAS DataBase Reference)
NIST Chemistry ReferenceMelatonin(73-31-4)
Safety Information
Hazard Codes T,F
Risk Statements 60-39/23/24/25-23/24/25-11
Safety Statements 24/25-99-53-45-36/37-16-7
RIDADR UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 2
RTECS AC5955000
8-10-23
HS Code 29379000
Hazardous Substances Data73-31-4(Hazardous Substances Data)
ToxicityLD50 orally in Rabbit: > 3200 mg/kg
MSDS Information
ProviderLanguage
Melatonine English
ACROS English
SigmaAldrich English
Melatonine Usage And Synthesis
descriptionMelatonin is a hormone secreted by the pineal gland, and its chemical structure was 5-methoxy-N-acetyl tryptamine, the physiological function of inhibiting gonad, thyroid, adrenal gland, parathyroid gland and pituitary function, inhibit precocious puberty, reduce pituitary Melanotropin secretion; and has a central nervous system function, can improve the convulsion the threshold, cause drowsiness. When pinealectomy after the animal experiment showed hyperplasia of the glands, weight increase, especially sex and sexual organs of immature rats early, pituitary secretion of LH and FSH increased, increasing secretion of thyroid and adrenal cortex hormone melatonin. More reduced pituitary MSH and whiten the skin of this role. Effects on the central nervous system, in the human EEG showed slow rhythm, increased seizure threshold, sleepiness, but does not affect their behavior and personality, of temporal lobe epilepsy and Ba Jinsen disease can reduce the motor nerve Abnormal EEG changes.
Chemical propertiesWhite or almost white crystalline powder.
Uses1. Melatonin can be used as medicine health care products, so as to enhance people’s immune function, preventing aging and back to youth. What’s more, it is also a kind of natural “sleeping pill”.
2. Melatonin is a kind of hormone secreted by pineal body of pituitary gland in the body. The amount of melatonin has something to do with light. The weaker the light is, the more the melatonin is, whereas the less. In addition, it is helpful to one’s sleep.
3. Biochemical research.
Physiological functions1. The effect to brain: the melatonin obtained by brain mainly gathers in midbrain and hypothalamus and it adds the activity of brain pyridoxal kinase, thus promoting glutamic acid decarboxylation to γ-amino butyric acid, 5-hydroxytryptophane decarboxylation to 5-hydroxytryptamine, both of which can inhibit the increase of the neurotransmitter content and have an effect of adjustment and mitigation on central nervous system.
2. The effect to hypothalamus and pituitary: materials like polypeptide produced by pineal body still have thyrotropin-releasing hormone(TRH) and luteinizing hormone releasing hormone(LRH) which are same with what hypothalamus produces except AVT. After injection of melatonin, gonadotropin (GnH)(FSH,LH) and melanocyte stimulating hormone(MSH) are lowered while growth hormone increases. Cutting pineal gland will cause pituitary hypertrophy, increase pituitary secretion and lower prolactin(PRL) and antidiuretic hormone (ADH).
3. The relation to gonad: melatonin has an inhibitory effect on the reproductive system. Clinically, main cytoma of pineal body can lead to pubertal delay and when teratoma appears in pineal body, it may result in sexual precocity because main cells are excluded. Ambient light and sympathetic nerve can affect the function of the reproductive system by inhibiting the synthesis and release of melatonin in pineal gland.
4. The relation to thyroid: by injecting melatonin, thyroid secretion will decrease. This may be caused through the inhibition of the hypothalamus release and Thyroid Stimulating Hormone (TSH) secretion of pituitary, hence holding back the function of thyroid.
5. The relation to adrenal cortex: melatonin has a strong inhibitory effect on adrenal cortex. If we inject pineal body extracts to healthy people, we will find that their aldosterone secretion and 17-ketosteroid output will decrease.
6. The relation to pancreatic island: melatonin can lower blood glucose and increase sugar tolerance. In conclusion, pineal gland can assist pituitary to jointly adjust endocrine function and play an vital role in keeping relatively constant in body environment and controlling some endocrine function, especially for gonad.
Synthesis of MelatoninPineal cells obtain tryptophan from blood circulation and become 5-hydroxytryptophane catalyzed by hydroxylase and 5-hydroxytryptophane turns into 5-hydroxytryptamine after decarboxylated by decarboxylase. There are three possible changes for 5-hydroxytryptamine: for the first part it may turn into 5-hydroxyl-benzpyrole acetic acid when deaminated by monoamine oxidase; for another part, some 5-hydroxytryptamine will leave the pineal cell and be taken in by sympathetic nerve ending and stored with neurotransmitter and noradrenalin; for the remaining part, the 5-hydroxytryptamine will be acetylated by N-acetyl-5-hydroxy tryptamine transferase and then be o-methoxy by hydroxylation indole-o-methyl converzyme, finally forming melatonin. After being synthesized, melatonin will be released by cells and enter into blood circulation through cerebrospinal fluid or directly, where noradrenalin may strengthen the synthesis, the speed of which depends on activity of hydroxylase in liver microsomes. Catalyzed by the hydroxylase, 6-hydroxylmelatonin is formed, soon afterwards it combines with glucuronic acid and sulfate, excreting through urine.
Chemical PropertiesOff-White Powder
UsesMelatonine can be used in sleep induction, modifies circadian rhythm, antioxidant, free radical scavenger
UsesImmunostimulant;Melatonin receptor ligand
UsesMelatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing apoptotic cell death of cancer cells. Inhibits proliferation/metastasis of breast cancer cells by inhibiting estrogen receptor action.
UsesHormone postulated to mediate photoperiodicity in mammals. Inhibits cerebellar nitric oxide synthetase
DefinitionChEBI: A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans.
World Health Organization (WHO)Melatonin is promoted as a cure for travel sickness, jet-lag and insomnia and has recently been claimed in the United States to reverse the ageing process. A synthetic version has been freely available from health food shops and pharmacies as a "nutritional supplement" since 1993.
Biological ActivityEndogenous hormone that acts as an agonist at melatonin receptors MT 1 and MT 2 . Exhibits a prominent role in the control of circadian rhythm, displays immunomodulatory activity and acts as a powerful antioxidant in vivo .
Veterinary Drugs and TreatmentsMelatonin may be useful to treat Alopecia-X in Nordic breeds, canine pattern baldness, or canine recurrent flank alopecia in dogs. It has been used anecdotally for the treatment of sleep cycle disorders in cats and geriatric dogs and to treat phobias and separation anxiety in dogs. Melatonin implants are used in the mink and fox pelt industries to promote the development of luxurious hair coats. Implants are also used to improve early breeding and ovulation rates in sheep and goats. Preliminary research is being done for this purpose in horses also.
In pigs, one study (Bubenik, Ayles et al. 1998) demonstrated that 5 mg/kg in feed reduced the incidence of gastric ulcers in young pigs.
Melatonine Preparation Products And Raw materials
Tag:Melatonine(73-31-4) Related Product Information
Ethylparaben 2-(2-Aminoethylamino)ethanol Acetylacetone Acetyl chloride Ethyl formate 3-Methoxybenzaldehyde Ethyl acetate Acetamide Ethyl propionate 4'-Methoxyacetophenone Ethyl acrylate p-Anisaldehyde Diethyl ether (Trifluoromethoxy)benzene p-Anisidine Ethylbenzene N-ACETYL-L-TYROSINE ETHYL ESTER Tetraacetylethylenediamine