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| | 5-Fluoroisatonic anhydride Basic information |
| Product Name: | 5-Fluoroisatonic anhydride | | Synonyms: | 6-FLUORO-2H-3,1-BENZOXAZINE-2,4(1H)-DIONE;6-fluoro-1H-benzo[d][1,3]oxazine-2,4-dione;6-fluoro-1H-3,1-benzoxazine-2,4-dione;6-fluoro-1H-3,1-benzoxazine-2,4-quinone;6-FLUORO ISATIN ANHYDRIDE;5-FLUOROISATONIC ANHYDRIDE;6-Fluorobenzo[d][1,3]oxazine-2,4-dione;NSC 149815 | | CAS: | 321-69-7 | | MF: | C8H4FNO3 | | MW: | 181.12 | | EINECS: | 640-488-8 | | Product Categories: | Miscellaneous;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 321-69-7.mol |  |
| | 5-Fluoroisatonic anhydride Chemical Properties |
| Melting point | 259-262°C | | density | 1.502±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | soluble in DMSO | | form | powder | | pka | 9.61±0.20(Predicted) | | color | Off-white to pale yellow | | CAS DataBase Reference | 321-69-7(CAS DataBase Reference) |
| Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | HazardClass | IRRITANT | | HS Code | 2934999090 |
| | 5-Fluoroisatonic anhydride Usage And Synthesis |
| Chemical Properties | Dark yellow Solid | | Uses | 5-Fluoroisatoic Anhydride is a versatile pharmaceutical intermediate used in the preparation of insulin secretagogues, HCV polymerase inhibitors, anxiolytic agents and other bioactive compounds. | | Preparation | 5-Fluoroisatonic anhydride is prepared from 5-fluoro indole (9d) by stirring in a 4:1 mixture of DMF/H2O for 16 h at room temperature.
1 H NMR (DMSO-d6): δ11.19 (s, br., 1H), 7.36 (dd, J = 8.4, 2.6 Hz, 1H), 6.87 (dt, J = 8.4, 2.2 Hz, 1H), 6.74 (dd, J = 9.3, 2.2 Hz, 1H).
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| | 5-Fluoroisatonic anhydride Preparation Products And Raw materials |
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