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Trichlormethiazide

Trichlormethiazide Suppliers list
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CAS:133-67-5
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Trichlormethiazide manufacturers

  • Trichlormethiazide
  • $30.00 / KG
  • 2022-01-21
  • CAS:133-67-5
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  • TRICHLORMETHIAZIDE
  • $10.00 / KG
  • 2021-12-08
  • CAS:133-67-5
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  • Trichlormethiazide
  • $200.00 / KG
  • 2021-11-17
  • CAS:133-67-5
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Trichlormethiazide Basic information
Product Name:Trichlormethiazide
Synonyms:6-CHLORO-3-DICHLOROMETHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE;6-chloro-3-(dichloromethyl)-3,4-dihydro-2h-1,2,4-benzothiadiazine-7-sulfonamid;6-Chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-thiadiazine-7-sulfonamide1,1-dioxide;6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide;6-chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamyl-1,2,4-benzothiadiazine-1,1;6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide;6-chloro-3-dichloromethyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dio;Achletin
CAS:133-67-5
MF:C8H8Cl3N3O4S2
MW:380.66
EINECS:205-118-8
Product Categories:METAHYDRIN
Mol File:133-67-5.mol
Trichlormethiazide Structure
Trichlormethiazide Chemical Properties
Melting point 248-250℃
Boiling point 631.3±65.0 °C(Predicted)
density 1.748
refractive index 1.6000 (estimate)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
pkapKa 6.9(acetone/H2O) (Uncertain)
Merck 14,9624
CAS DataBase Reference133-67-5(CAS DataBase Reference)
EPA Substance Registry SystemTrichlormethiazide (133-67-5)
Safety Information
Hazard Codes Xn
Risk Statements 42/43
Safety Statements 36
WGK Germany 2
RTECS DK8925000
HS Code 2935904000
Hazardous Substances Data133-67-5(Hazardous Substances Data)
ToxicityLD50 orally in rats: >20000 mg/kg (Goldenthal)
MSDS Information
ProviderLanguage
SigmaAldrich English
Trichlormethiazide Usage And Synthesis
Chemical PropertiesTrichlormethiazide occurs as a white or practically white, crystalline powder and may have a slight characteristic odor.
OriginatorNaqua,Schering,US,1960
Usesdiuretic, antihypertensive
UsesTrichlormethiazide, is a diuretic, having similar properties as Hydrochlorothiazide (H714560). It is used for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension.
UsesTrichlormethiazide is a diuretic and anti-hypertensive agent from the benzothiadiazide class which is used in veterinary medicine in cattle, sheep, goats, pigs and horses, at the following therapeutic regimen: a single intramuscular dose of 0.4 mg/kg bw followed by two oral doses of 0.8 mg/kg bw given 12 and 36 hours after the first administration.
Trichlormethiazide is also used in humans in the United States as a diuretic and anti-hypertensive substance but not in the European Union. The usual dose is 2 to 4 mg twice a day (i.e. approximately 0.033 to 0.066 mg/kg bw/day).
Manufacturing ProcessA mixture of 5.7 grams (0.02 mol) of 5-chloro-2,4-disulfamylaniline and 4.9 grams (0.04 mol) of dichloroacetaldehyde in 25 ml of dimethyl formamide was heated at the boiling temperature and under reflux for 30 minutes. The reaction mixture was thereafter poured into a mixture of ice and water to precipitate the desired 6-chloro-7-sulfamyl-3-dichloromethyl-3,4-dihydro- 1,2,4-benzothiadiazine-1,1-dioxide as a crystalline solid melting at 250° to 270°C with decomposition.
Therapeutic FunctionDiuretic
Trichlormethiazide Preparation Products And Raw materials
Raw materialsIsothiazolinones-->DICHLOROACETALDEHYDE-->4-Amino-6-chlorobenzene-1,3-disulfonamide
Tag:Trichlormethiazide(133-67-5) Related Product Information
Sucralose Tetracycline hydrochloride Hydrochlorothiazide Chlorothiazide 2-Aminobenzenesulfonamide 4-Chlorobenzenesulfonamide 2-AMINO-4-CHLOROTHIOPHENOL 2-AMINO-N-METHYLBENZENESULFONAMIDE 4-CHLORO-1,3-BENZENEDITHIOL 4-Amino-6-chlorobenzene-1,3-disulfonamide CLOFENAMIDE teclothiazide Trichlormethiazide 4-Chloro-N-methylbenzenesulphonamide Benzenesulfonamide, 2-(methylamino)- (9CI) 5-CHLORO-2-MERCAPTOANILINE HYDROCHLORIDE o-Chlorobenzenesulfonamide 2H-1,2,4-BENZOTHIADIAZINE, 3-(CHLOROMETHYL)-3,4-DIHYDRO-, 1,1-DIOXIDE (9CI)