ChemicalBook > Product Catalog >API >Antibiotics >Tetracycline drugs >Chlorotetracycline

Chlorotetracycline

Chlorotetracycline Suppliers list
Company Name: Shenzhen Sendi Biotechnology Co.Ltd.
Tel: 0755-23311925 18102838259
Email: Abel@chembj.com
Products Intro: Product Name:Chlorotetracycline
CAS:57-62-5
Purity:15% Package:16/KG
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:Chlorotetracycline
CAS:57-62-5
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:57-62-5
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Mainchem Co., Ltd.
Tel: +86-0592-6210733
Email: sales@mainchem.com
Products Intro: Product Name:Chlorotetracycline
CAS:57-62-5
Company Name: Shanghai Yingrui Biopharma Co., Ltd.
Tel: +86-21-33585366 E-mail:sales03@shyrchem.com
Email: sales03@shyrchem.com
Products Intro: Product Name:Chlorotetracycline
CAS:57-62-5
Purity:99% Package:100g;500g;1kg;25kg...
Chlorotetracycline Basic information
Description
Product Name:Chlorotetracycline
Synonyms:acronize;aureocina;aureomycina-377;aureomykoin;biomitsin;chlortetracycline;Aurofac 10;Biomycin A
CAS:57-62-5
MF:C22H23ClN2O8
MW:478.88
EINECS:200-341-7
Product Categories:PHARMACEUTICALS
Mol File:57-62-5.mol
Chlorotetracycline Structure
Chlorotetracycline Chemical Properties
Melting point 168-169°
alpha D23 -275.0° (methanol)
density 1.2833 (rough estimate)
refractive index 1.6000 (estimate)
storage temp. 2-8°C
pkapKa 3.3 (Uncertain)
CAS DataBase Reference57-62-5(CAS DataBase Reference)
EPA Substance Registry System2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)- 1,4,4a,5,5a,6,11,12a-octahydro- 3,6,10,12,12a-pentahydroxy- 6-methyl-1,11-dioxo-, (4S,4aS,5aS,6S,12aS)-(57-62-5)
Safety Information
Hazard Codes Xn
Risk Statements 22
WGK Germany 1
RTECS QI7750000
Chlorotetracycline Usage And Synthesis
DescriptionChlortetracycline (Brand name: Aureomycin) is the 7-chloro substitution derivative of the tetracycline and has a golden color. As a veterinary medicine, chlortetracycline is commonly used for the treatment of conjunctivitis of cats. It can also be used in the treatment of infections occurring in the urinary tract, respiratory tract, and the intestines. Its mechanism of action is through inhibiting the protein synthesis, inhibiting the binding of aminoacyl-tRNA to the mRNA-ribosome complex through binding to the 30S ribosome subunit.
UsesChlortetracycline was the first reported member of the tetracycline class, isolated from Streptomyces aureofaciens in 1948. Chlortetracyclines heralded the early wave of antibiotic discoveries from microbes and after 50 years are still widely used as pharmaceuticals. Chlortetracycline is a pigment and, like most pigments, is extremely sensitive to environmental and storage conditions. Commercial chlortetracycline may contain significant levels of degradation products.
DefinitionChEBI: A member of the class of tetracyclines with formula C22H23ClN2O8 isolated from Streptomyces aureofaciens.
Antimicrobial activityIt is slightly less active than tetracycline against many bacteria, with the exception of Gram-positive organisms.
Pharmaceutical Applications7-Chlortetracycline. A fermentation product of certain strains of Streptomyces aureofaciens. Formulated as the hydrochloride or the free base for oral or topical application.
PharmacokineticsOral absorption:30–60%
Cmax 500 mg oral:2.5–7 mg/L:
Plasma half-life: 5–6 h
Volume of distribution: c.2 L/kg
Plasma protein binding: 47–65%
Absorption is relatively poor compared with other tetracyclines. It undergoes rapid metabolism and is largely eliminated by biliary excretion, with only a small proportion eliminated via the kidney. Despite this, chlortetracycline is not recommended for patients in renal failure, since accumulation occurs as a consequence of the half-life increase to approximately 7–11 h.
Clinical UseIts uses are those common to the group. It has also been used topically in the management of recurrent aphthous ulcers of the mouth, but experience is limited and the mechanism of action is unknown.
Side effectsSide effects are typical of the group. Contact hypersensitivity has been reported with topical application to abraded skin and varicose ulcers.
Safety ProfilePoison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cland NOx. See also TETRACYCLINE.
Purification MethodsAureomycin is dehydrated by azeotropic distillation of its solution with toluene. On cooling, the anhydrous material crystallises out and is recrystallised from *C6H6, then dried under vacuum at 100o over paraffin wax. (If it is crystallised from MeOH, it contains MeOH which is not removed on drying.) [Stephens et al. J Am Chem Soc 76 3568 1954, Laskin & Chan Biochem Biophys Res Commun 14 137 1964]. [Beilstein 14 IV 2631.]
Chlorotetracycline Preparation Products And Raw materials
Preparation Products5'-Deoxyadenosylcobalamin
Raw materialsXANTHOPTERIN
Tag:Chlorotetracycline(57-62-5) Related Product Information
(S)-2-METHYL-1-PHENYL-BUT-3-EN-1-OL Tetracycline 4-Methyl-1-tetralone 5-Chloro-1-tetralone (S)-1-PHENYL-BUT-3-EN-1-OL 1,2,3,4-Tetrahydro-1-naphthol 1,2,3,4-TETRAHYDRO-1,5-NAPHTHALENEDIOL CHLOROTETRACYCLINE HYDROCHLORIDEVETRANAL , 250 MG,4-Chlorotetracycline hydrochloride,7-CHLOROTETRACYCLINE HCL,7-CHLOROTETRACYCLINE MONOHYDROCHLORIDE,7-CHLOROTETRACYCLINE HYDROCHLORIDE,CHLOROTETRACYCLINE HCL,CHLOROTETRACYCLINE HYDROCHLORIDE Tetracycline hydrochloride 4-(2-Chlorophenyl)-2-methylbut-1-ene Chlorotetracycline 4-Dimethylaminopyridine 3-Dimethylaminopropylamine 1,4-Dioxane 4-Dimethylaminobenzoic acid Difluorochloromethane 4-Dimethylaminobenzaldehyde 2-Dimethylaminoethanol