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2,5-Dimethylpiperazine

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CAS:106-55-8
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CAS:106-55-8
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Products Intro: Product Name:2,5-dimethylpiperazine
CAS:106-55-8

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2,5-Dimethylpiperazine Basic information
Product Name:2,5-Dimethylpiperazine
Synonyms:Aids060673;Aids-060673;(2R,5S)-2,5-DiMethyl-piperazine;2,5-Dimethylpiperazine，mixturi of cis and trans;Piperazine, 2,5-dimethyl-;2,5-dimethyl-piperazin;2,5-Dimethylpiperazine,c&t;cis-trans-2,5-Dimethyl piperazine
CAS:106-55-8
MF:C6H14N2
MW:114.19
EINECS:203-409-4
Product Categories:
Mol File:106-55-8.mol
2,5-Dimethylpiperazine Structure
2,5-Dimethylpiperazine Chemical Properties
Melting point 113-118 °C
Boiling point 162-165 °C
density 0.53
refractive index 1.4628 (estimate)
Fp 58 °C
storage temp. 2-8°C
pka9.66(at 25℃)
InChIInChI=1S/C6H14N2/c1-5-3-8-6(2)4-7-5/h5-8H,3-4H2,1-2H3
InChIKeyNSMWYRLQHIXVAP-UHFFFAOYSA-N
SMILESN1CC(C)NCC1C
CAS DataBase Reference106-55-8(CAS DataBase Reference)
NIST Chemistry ReferencePiperazine, 2,5-dimethyl-(106-55-8)
EPA Substance Registry SystemPiperazine, 2,5-dimethyl- (106-55-8)
Safety Information
Hazard Codes C-F
Risk Statements 34-21-11
Safety Statements 45-36/37/39-26-16
TSCA TSCA listed
Toxicityrabbit,LD50,skin,800uL/kg (0.8mL/kg),AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951.
MSDS Information
ProviderLanguage
ACROS English
2,5-Dimethylpiperazine Usage And Synthesis
Chemical PropertiesTrans-2,5-Dimethylpiperazine, a white crystalline solid melting at 118° C., has shown particular promise as an intermediate for linear polyamides because of its symmetry. The cis isomer, a liquid freezing at about 18° C., probably has limited use in polymers but is expected to be useful as a pharmaceutical intermediate.[2]
UsesTrans-2,5-dimethylpiperazine is primarily as a monomer for synthesizing a specific polyamide polymer, which is then used as a material for reverse osmosis membranes.[1]
SynthesisIn the presence of hydrogenation-dehydrogenation catalysts, isopropanolamine undergoes a bimolecular cycloamination reaction to form 2,5-dimethylpiperazine[2]:
2,5-Dimethylpiperazine synthesis
References [1] L. CREDALI   P. P  A Chiolle. Reverse osmosis properties of poly(trans-2,5-dimethylpiperazine fumaramide) films[J]. Polymer, 1972, 13 10: Pages 503-506. DOI:10.1016/0032-3861(72)90090-0.
[2] W. LANGDON   D. J  W Levis. 2,5-Dimethylpiperazine Synthesis from Isopropanolamine[J]. Industrial & Engineering Chemistry Process Design and Development, 1962, 64 1: 153-156. DOI:10.1021/I260002A016.
Tag:2,5-Dimethylpiperazine(106-55-8) Related Product Information
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