- 4,6-Dichloronicotinic acid
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- $3.00 / 25KG
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2026-04-17
- CAS:73027-79-9
- Min. Order: 0.1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
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| | 4,6-Dichloronicotinic acid Basic information |
| Product Name: | 4,6-Dichloronicotinic acid | | Synonyms: | 2,4-DICHLORO-5-PYRIDINE-5-CARBOXYLIC ACID;2,4-DICHLORO-5-CARBOXYLPYRIDINE;2,4-DICHLOROPYRIDINE-5-CARBOXYLIC ACID;4,6-DICHLORONICOTINIC ACID;2,4-Dichloro-5-carboxypyridine;2,4-Dichloro-5-pyridinecarboxylic acid;2,4-Dichloro-5-carboxylpyridine ,97%;4,6-Dichloronicotinic acid ,97% | | CAS: | 73027-79-9 | | MF: | C6H3Cl2NO2 | | MW: | 192 | | EINECS: | 695-891-1 | | Product Categories: | Pyridine;Pyridines | | Mol File: | 73027-79-9.mol |  |
| | 4,6-Dichloronicotinic acid Chemical Properties |
| Melting point | 158-160 | | Boiling point | 337.0±37.0 °C(Predicted) | | density | 1.612±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | pka | 1.87±0.25(Predicted) | | form | Solid | | color | White to Light yellow | | Water Solubility | Slightly soluble in water. | | Stability: | Hygroscopic | | InChI | InChI=1S/C6H3Cl2NO2/c7-4-1-5(8)9-2-3(4)6(10)11/h1-2H,(H,10,11) | | InChIKey | ILMIEWNDXAKVNI-UHFFFAOYSA-N | | SMILES | C1=NC(Cl)=CC(Cl)=C1C(O)=O | | CAS DataBase Reference | 73027-79-9(CAS DataBase Reference) |
| | 4,6-Dichloronicotinic acid Usage And Synthesis |
| Chemical Properties | White solid | | Uses | 4,6-Dichloronicotinic acid is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff fields. | | Synthesis | General procedure for the synthesis of 4,6-dichloronicotinic acid from ethyl 4,6-dichloronicotinate: to a stirred solution of ethyl 4,6-dichloronicotinate (22) (25.95 g, 118 mmol) dissolved in 4:1:1 THF:MeOH:water (600 mL) was added sodium hydroxide solution (40 mL, 6.25 M). After 30 min of reaction, the reaction mixture was acidified to pH 2 with concentrated hydrochloric acid and subsequently diluted with 1:1 EtOAc:Et2O and washed sequentially with water and brine. The organic layer was dried over anhydrous sodium sulfate and concentrated. The resulting off-white solid was purified by concentrating twice from toluene to give the final target product 4,6-dichloronicotinic acid (23) as a white solid (21.73 g, 96% yield). | | References | [1] Patent: US2005/49419, 2005, A1. Location in patent: Page/Page column 24
[2] Patent: US2005/54701, 2005, A1
[3] Tetrahedron Letters, 2011, vol. 52, # 4, p. 512 - 514
[4] Patent: WO2014/52365, 2014, A1. Location in patent: Page/Page column 229-230
[5] Patent: US2015/191464, 2015, A1. Location in patent: Paragraph 0611 |
| | 4,6-Dichloronicotinic acid Preparation Products And Raw materials |
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