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| | PUROMYCIN AMINONUCLEOSIDE Basic information |
| Product Name: | PUROMYCIN AMINONUCLEOSIDE | | Synonyms: | 3’-amino-3’-deoxy-n,n-dimethyl-adenosin;6-(dimethylamino)-9-(3-amino-3-deoxy-beta-d-ribofuranosyl)purine;9-(3-amino-3-deoxy-beta-d-ribofuranosyl)-6-(dimethylamino)-9h-purine;aminonucleoside;aminonucleosidepuromycin;stylomycinaminonucleoside;PUROMYCIN AMINONUCLEOSIDE;6-DIMETHYLAMIN-9-[3'-AMINO-3'DEOXYRIBOSYL]-PURINE | | CAS: | 58-60-6 | | MF: | C12H18N6O3 | | MW: | 294.31 | | EINECS: | 200-388-3 | | Product Categories: | | | Mol File: | 58-60-6.mol |  |
| | PUROMYCIN AMINONUCLEOSIDE Chemical Properties |
| Melting point | 235℃ (Decomposition) | | Boiling point | 436.08°C (rough estimate) | | density | 1.2131 (rough estimate) | | refractive index | 1.7000 (estimate) | | Fp | >110°(230°F) | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | H2O: 50 mg/mL, clear, slightly yellow | | form | liquid | | pka | 13.26±0.70(Predicted) | | color | White | | Water Solubility | Soluble in water at 50mg/ml. May require heating | | BRN | 93902 | | Stability: | Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months. | | InChIKey | RYSMHWILUNYBFW-GRIPGOBMSA-N | | EPA Substance Registry System | Adenosine, 3'-amino-3'-deoxy-N,N-dimethyl- (58-60-6) |
| Hazard Codes | Xi,Xn | | Risk Statements | 48/22 | | WGK Germany | 3 | | RTECS | AU7337000 | | F | 10-21 | | TSCA | Yes | | HS Code | 29419090 |
| | PUROMYCIN AMINONUCLEOSIDE Usage And Synthesis |
| Description | Puromycin aminonucleoside (58-60-6) is the nucleoside moiety of puromycin (Cat.# 10-2100) which does not inhibit protein synthesis or induce apoptosis.1?It acts as a glomerular epithelial cell toxin2 and as such is a useful tool for producing animal models of nephropathy3,4, or puromycin aminonucleoside nephrosis (1-2.5 mg/100g rat body weight)5. Active in vivo. | | Chemical Properties | White crystal | | Uses | Puromycin aminonucleoside is a semi-synthetic derivative of puromycin which lacks the methoxyphenylalanyl moiety. Puromycin aminonucleoside is the key intermediate in the synthesis of semi-synthetic analogues of puromycin. It does not inhibit protein synthesis or induce apoptosis, but exhibits antitumour properties. Puromycin aminonucleoside-induced nephrosis is a well-described model of human idiopathic nephrotic syndrome, suppressing integrin expression in cultured glomerular epithelial cells. | | Uses | Puromycin Aminonucleoside is an aminonucleoside portion of the antibiotic puromycin. | | Definition | ChEBI: Puromycin derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. | | Safety Profile | An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx,. | | References | [1] SEK C. CHOW Sten O Iris Peters. Reevaluation of the Role of de Novo Protein Synthesis in Rat Thymocyte Apoptosis[J]. Experimental cell research, 1995, 216 1: Pages 149-159. DOI:10.1006/excr.1995.1019
[2] Puromycin aminonucleoside suppresses integrin expression in cultured glomerular epithelial cells
[3] YUKARI EGASHIRA Hiroo S Shin Nagaki. Tryptophan-niacin metabolism in rat with puromycin aminonucleoside-induced nephrosis.[J]. International Journal for Vitamin and Nutrition Research, 2006, 76 1: 28-33. DOI:10.1024/0300-9831.76.1.28
[4] M. HAGIWARA . Mitochondrial dysfunction in focal segmental glomerulosclerosis of puromycin aminonucleoside nephrosis[J]. Kidney international, 2006, 69 7: Pages 1146-1152. DOI:10.1038/sj.ki.5000207
[5] E K LÖWENBORG U B B G Jaremko. Glomerular function and morphology in puromycin aminonucleoside nephropathy in rats.[J]. Nephrology Dialysis Transplantation, 2000, 15 10: 1547-1555. DOI:10.1093/ndt/15.10.1547 |
| | PUROMYCIN AMINONUCLEOSIDE Preparation Products And Raw materials |
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