| Company Name: |
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd
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| Tel: |
021-59167510 18117107507 |
| Email: |
vip@med-life.cn |
| Products Intro: |
Product Name:CFTR corrector 6
CAS:2226970-01-8
Purity:>=99% Package:10mg;25mg;200mg;500mg;100mg;5mg;50mg
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| | PF-06860932 Basic information |
| Product Name: | PF-06860932 | | Synonyms: | PF-06860932;CFTR corrector 6;7H-Pyrrolo[2,3-d]pyrimidine-6-carbonitrile, 4-amino-7-[[1-(2-fluorophenyl)-1H-pyrazol-4-yl]methyl]-5-[2-(trifluoromethyl)-5-pyrimidinyl]- | | CAS: | 2226970-01-8 | | MF: | C22H13F4N9 | | MW: | 479.39 | | EINECS: | | | Product Categories: | | | Mol File: | 2226970-01-8.mol |  |
| | PF-06860932 Chemical Properties |
| Boiling point | 697.4±55.0 °C(Predicted) | | density | 1.60±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | pka | 3.23±0.30(Predicted) | | form | Solid | | color | White to off-white |
| | PF-06860932 Usage And Synthesis |
| Biological Activity | CFTR corrector 6 is a potent potentiator of Cystic Fibrosis Transmembrane conductance Regulator (CFTR). CFTR corrector 6 has the potential for cystic fibrosis (CF) and other CFTR associated disorders research[1].
CFTR corrector 6 (Example 27) has EC50s of 1.25 nM and 1.27 nM for primary cystic fibrosis human bronchial epithelial (CF hBE) cells and fischer rat thyroid (FRT) cell lines[1]. | | References | [1]. Joseph Walter Strohbach, et al. Pyrrolopyrimidines as cftr potentiators. WO2018094137A1 |
| | PF-06860932 Preparation Products And Raw materials |
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