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| | GLX351322 Basic information |
| Product Name: | GLX351322 | | Synonyms: | CS-2871;GLX 351322;GLX-351322;4H-Cyclopenta[b]thiophene-3-carboxylic acid, 2-[[2-[4-(2-furanylcarbonyl)-1-piperazinyl]acetyl]amino]-5,6-dihydro-, ethyl ester;GLX351322,GLX-351322,GLX 351322,NADPH Oxidase,NOX,Inhibitor,inhibit;Ethyl 2-(2-(4-(furan-2-carbonyl)piperazin-1-yl)acetamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate | | CAS: | 835598-94-2 | | MF: | C21H25N3O5S | | MW: | 431.51 | | EINECS: | | | Product Categories: | | | Mol File: | 835598-94-2.mol |  |
| | GLX351322 Chemical Properties |
| solubility | DMSO:20.0(Max Conc. mg/mL);46.35(Max Conc. mM)
DMF:1.0(Max Conc. mg/mL);2.32(Max Conc. mM)
DMF:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.76(Max Conc. mM)
Ethanol:4.0(Max Conc. mg/mL);9.27(Max Conc. mM) | | form | A crystalline solid |
| | GLX351322 Usage And Synthesis |
| Biological Activity | GLX351322 is an inhibitor of NADPH oxidase 4 (NOX4). It can inhibits tetracycline-induced hydrogen peroxide production in NOX4-overexpressing cells with IC50 of 5 μM. | | in vitro | GLX351322 is an inhibitor of NADPH oxidase 4, and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC 50 of 5 μM. GLX351322 shows weak activity against NOX2 in hPBMC cells ( IC 50 , 40 μM). | | in vivo | GLX351322 (3.8 mg/kg/day, po) ameliorates HFD-induced hyperglycemia in mice. | | target | | Target | Value | NOX4
(Cell-free assay) | 5 μM |
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| | GLX351322 Preparation Products And Raw materials |
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