- TH34
-
- $38.00 / 1mg
-
2025-11-10
- CAS:2196203-96-8
- Min. Order:
- Purity: 98.32%
- Supply Ability: 10g
- TH34
-
- $9.80 / 1.79999995231628KG
-
2020-01-09
- CAS:2196203-96-8
- Min. Order: 1g
- Purity: ≥99%
- Supply Ability: 100kg
|
| Product Name: | TH34 | | Synonyms: | TH34;CS-2858;TH34;TH 34;3-(Benzylamino)-N-hydroxy-4-methylbenzamide;TH34,inhibit,Inhibitor,TH 34,TH-34,HDAC,Histone deacetylases;Benzamide, N-hydroxy-4-methyl-3-[(phenylmethyl)amino]-;TH34, 10 mM in DMSO | | CAS: | 2196203-96-8 | | MF: | C15H16N2O2 | | MW: | 256.3 | | EINECS: | | | Product Categories: | | | Mol File: | 2196203-96-8.mol |  |
| density | 1.236±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | DMSO : 150 mg/mL (585.25 mM) | | pka | 9.04±0.10(Predicted) | | form | Solid | | color | White to off-white |
| Uses | TH34, an HDAC6/8/10 inhibitor with IC50s of 4.6 μM, 1.9 μM, and 7.7 μM respectively, shows high selectivity over HDAC1/2/3[1]. | | Biological Activity | TH34 is an HDAC6/8/10 inhibitor with IC50 values of 4.6 μM, 1.9 μM and 7.7 μM, respectively, showing high selectivity compared with HDAC1/2/3. | | in vitro | TH34 induces caspase-dependent programmed cell death and cell cycle arrest in neuroblastoma cells. | | target | | HDAC6 4.6 μM (IC 50 ) | HDAC8 1.9 μM (IC 50 ) | HDAC10 7.7 μM (IC 50 ) | | | IC 50 | HDAC6: 4.6 μM (IC50); HDAC8: 1.9 μM (IC50); HDAC10: 7.7 μM (IC50) | | References | [1] Kolbinger FR, et al. The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines. Arch Toxicol. 2018 Aug;92(8):2649-2664. DOI:10.1007/s00204-018-2234-8 |
| | TH34 Preparation Products And Raw materials |
|