| Company Name: |
Shanghai YuanYe Biotechnology Co., Ltd.
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| Tel: |
021-61312847; 18021002903 |
| Email: |
3008007409@qq.com |
| Products Intro: |
Product Name:VU 0364739 HYDROCHLORIDE
CAS:1244640-48-9
Purity:>=98%(HPLC) Package:10mg Remarks:T87717
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| Company Name: |
BOC Sciences
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| Tel: |
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| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:VU 0364739 hydrochloride
CAS:1244640-48-9
Purity:≥98% by HPLC Remarks:VU 0364739 hydrochloride is a potent and selective phospholipase D2 (PLD2) inhibitor (IC50 = 20 nM), displaying 75-fold selectivity over PLD1 (IC50 = 1500 nM).
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VU 0364739 HYDROCHLORIDE manufacturers
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| | VU 0364739 HYDROCHLORIDE Basic information |
| | VU 0364739 HYDROCHLORIDE Chemical Properties |
| storage temp. | Desiccate at RT | | solubility | Soluble to 100 mM in DMSO | | form | Powder | | color | white to beige |
| | VU 0364739 HYDROCHLORIDE Usage And Synthesis |
| Uses | VU 0364739 Hydrochloride is a selective, small molecule inhibitor of phopholipase D2. | | Biological Activity | PLD2-selective, PH domain-targeting phospholipase D allosteric inhibitor with in vitro and in vivo efficacy.
VU0364739 is a PLD2-selective, PH domain-targeting phospholipase D allosteric inhibitor (PLD2/PLD1 IC50 = 100 nM/7.5 μM by enzymatic assay) th at selectively suppresses the cellular PLD activity in GFP-PLD2-overexpressing HEK293 cells over PMA-stimulated non-small-cell lung cancer (NSCLC) Calu-1 cells with predominant PLD1 activity (IC50 = 20 nM and 1.5 μM, respectively). VU0364739 is reported to suppress PLD2-dependent proliferation in cultures (by 56% in 48 hrs; MDA-MB-231, 10 μM) and alleviate the symptoms of DSS-induced colitis in mice in vivo (10 mg/kg i.p. qod). | | in vivo | 1.19 Pharmacokinetic Properties of VU 0364739 in Rats[1]. | Rats
IV 1 mg/kg | Rats
PO 10 mg/kg | | CL (mL/min/kg) | 61.5 | | | t1/2 (h) | 1.52 | | | Vdss (L/kg) | 8.1 | | | plasma (ng/mL) | | 39.9 | | brain (ng/mL) | | 29 | |
| | IC 50 | PLD2: 20 nM (IC50); PLD1: 1500 nM (IC50) | | storage | Desiccate at RT |
| | VU 0364739 HYDROCHLORIDE Preparation Products And Raw materials |
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