| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
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| Products Intro: |
Product Name:CP-424,174
CAS:210825-31-3
Purity:>=98% (HPLC) Package:5MG Remarks:PZ0347-5MG
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| | CP-424,174 Basic information |
| Product Name: | CP-424,174 | | Synonyms: | CP-424,174;N-[[[4-Chloro-2,6-bis(1-methylethyl)phenyl]amino]carbonyl]-3-(1-hydroxy-1-methylethyl)benzenesulfonamide;Benzenesulfonamide, N-[[[4-chloro-2,6-bis(1-methylethyl)phenyl]amino]carbonyl]-3-(1-hydroxy-1-methylethyl)-;CP-424,174 >=98% (HPLC);N-((4-Chloro-2,6-diisopropylphenyl)carbamoyl)-3-(2-hydroxypropan-2-yl)benzenesulfonamide;CP424174,IL-1β,NLRP3,Inhibitor,CP 424174,CP-424174,Inflammasome,inhibit,NOD-like Receptor (NLR) | | CAS: | 210825-31-3 | | MF: | C22H29ClN2O4S | | MW: | 452.99 | | EINECS: | | | Product Categories: | | | Mol File: | 210825-31-3.mol |  |
| | CP-424,174 Chemical Properties |
| density | 1?+-.0.06 g/cm3(Predicted) | | storage temp. | room temp | | solubility | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:5): 0.16 mg/ml | | pka | 4.67±0.10(Predicted) | | form | powder | | color | white to beige |
| | CP-424,174 Usage And Synthesis |
| Biochem/physiol Actions | CP-424,174 is a cytokine release inhibitory drugs (CRID) that inhibits the post-translational processing and secretion of IL-1b in response to LPS and ATP in human monocytes. It is quite possible that similarly to CP-456,773 (termed CRID3), CP-424,174 inhibits both NLRP3 and AIM2 inflammasomes by preventing ASC oligomerisation. |
| | CP-424,174 Preparation Products And Raw materials |
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