BR351 manufacturers
- BR351
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- $1670.00 / 25mg
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2024-10-28
- CAS:960113-85-3
- Min. Order:
- Purity:
- Supply Ability: 10g
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| Product Name: | BR351 | | Synonyms: | BR351;BR351,BR-351;Butanamide, 2-[[[4-(2-fluoroethoxy)phenyl]sulfonyl](phenylmethyl)amino]-N-hydroxy-3-methyl-, (2R)-;(R)-2-(N-Benzyl-4-(2-fluoroethoxy)phenylsulfonamido)-N-hydroxy-3-methylbutanamide | | CAS: | 960113-85-3 | | MF: | C20H25FN2O5S | | MW: | 424.49 | | EINECS: | | | Product Categories: | | | Mol File: | 960113-85-3.mol |  |
| | BR351 Chemical Properties |
| density | 1.279±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 9.15±0.40(Predicted) |
| | BR351 Usage And Synthesis |
| Description | BR351 is a brain penetrant MMP inhibitor for MMP2, MMP8, MMP9 and MMP13, respectively. | | Uses | BR351 is a brain penetrant MMP inhibitor with IC50s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively[1]. | | IC 50 | MMP-9: 11 nM (IC50); MMP-2: 4 nM (IC50); MMP-8: 2 nM (IC50); MMP13: 50 nM (IC50) | | References | [1] Wagner S, et al. Novel fluorinated derivatives of the broad-spectrum MMP inhibitors N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](benzyl)- and (3-picolyl)-amino]-3-methyl-butanamide as potential tools for the molecular imaging of activated MMPs with PET. J DOI:10.1021/jm0708533 |
| | BR351 Preparation Products And Raw materials |
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