CU-3
(DGKα inhibitor CU-3) manufacturers
- (5Z,2E)-CU-3
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- $378.00 / 25mg
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2025-08-22
- CAS:1815598-71-0
- Min. Order:
- Purity: 99.02%
- Supply Ability: 10g
- (5Z,2E)-CU-3
-
- $378.00 / 25mg
-
2024-10-28
- CAS:1815598-71-0
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | CU-3
(DGKα inhibitor CU-3) Basic information |
| Product Name: | CU-3
(DGKα inhibitor CU-3) | | Synonyms: | 2E)-CU-3;Benzenesulfonamide, N-[(5Z)-5-[(2E)-3-(2-furanyl)-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidinyl]-;DGKα inhibitor CU-3;(5Z,2E)-CU-3;CU-3
(DGKα inhibitor CU-3);(5Z,2E)CU3,(5Z,2E) CU 3;5-[(2E)-3-(2-furyl)prop-2-enylidene]-3-[(phenylsulfonyl)amino]2-thioxo-1,3-thiazolidin-4-one;N-[(5Z)-5-[(2E)-3-(2-furanyl)-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidinyl]-benzenesulfonamide | | CAS: | 1815598-71-0 | | MF: | C16H12N2O4S3 | | MW: | 392.47 | | EINECS: | | | Product Categories: | | | Mol File: | 1815598-71-0.mol |  |
| | CU-3
(DGKα inhibitor CU-3) Chemical Properties |
| Boiling point | 561.8±60.0 °C(Predicted) | | density | 1.58±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 20 mg/mL (50.96 mM; ultrasonic and warming and heat to 60°C) | | pka | 4.72±0.20(Predicted) | | form | A solid | | color | Yellow to brown | | Water Solubility | Water: < 0.1 mg/mL (insoluble) |
| | CU-3
(DGKα inhibitor CU-3) Usage And Synthesis |
| Uses | (5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells[1]. | | References | [1] Liu K, et al. A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response. J Lipid Res. 2016 Mar;57(3):368-79. DOI:10.1194/jlr.M062794 |
| | CU-3
(DGKα inhibitor CU-3) Preparation Products And Raw materials |
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