Sign in | Register | china | japan | germany

N-Cyclopropyl-2,4-difluoro-5-[[[2-(2-pyridinylamino)-5-thiazolyl]methyl]amino]benzamide

Request For Quotation
N-Cyclopropyl-2,4-difluoro-5-[[[2-(2-pyridinylamino)-5-thiazolyl]methyl]amino]benzamide Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:BMS 605541
CAS:639858-32-5
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:BMS-605541
CAS:639858-32-5
Purity:98.07% Package:5mg;45USD|10mg;73USD|25mg;157USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Aladdin Scientific
Tel:
Email: tp@aladdinsci.com
Products Intro: Product Name:BMS 605541
CAS:639858-32-5
Purity:>=98%(HPLC) Package:$93.9/5mg;$147.9/10mg;$315.9/25mg;$513.9/50mg;Bulk package Remarks:98%(HPLC)
Company Name: Shanghai Lollane Biological Technology Co.,Ltd.  
Tel: 021-52996696，15000506266 15000506266
Email:
Products Intro: Product Name:BMS605541
CAS:639858-32-5
Purity:98% HPLC Package:5mg，10mg，50mg，100mg，1g，5g
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Email: info@efebio.com
Products Intro: Product Name:BMS 605541
CAS:639858-32-5
Purity:98% Package:1mg;5mg;10mg

N-Cyclopropyl-2,4-difluoro-5-[[[2-(2-pyridinylamino)-5-thiazolyl]methyl]amino]benzamide manufacturers

  • BMS-605541
  • BMS-605541 pictures
  • $66.00 / 25mg
  • 2025-11-09
  • CAS:639858-32-5
  • Min. Order:
  • Purity: 98.07%
  • Supply Ability: 10g
N-Cyclopropyl-2,4-difluoro-5-[[[2-(2-pyridinylamino)-5-thiazolyl]methyl]amino]benzamide Basic information
Product Name:N-Cyclopropyl-2,4-difluoro-5-[[[2-(2-pyridinylamino)-5-thiazolyl]methyl]amino]benzamide
Synonyms:N-Cyclopropyl-2,4-difluoro-5-[[[2-(2-pyridinylamino)-5-thiazolyl]methyl]amino]benzamide;BMS 605541;Benzamide, N-cyclopropyl-2,4-difluoro-5-[[[2-(2-pyridinylamino)-5-thiazolyl]methyl]amino]-;Lenvatinib-d;BMS-605541, 10 mM in DMSO
CAS:639858-32-5
MF:C19H17F2N5OS
MW:401.43
EINECS:
Product Categories:
Mol File:639858-32-5.mol
N-Cyclopropyl-2,4-difluoro-5-[[[2-(2-pyridinylamino)-5-thiazolyl]methyl]amino]benzamide Structure
N-Cyclopropyl-2,4-difluoro-5-[[[2-(2-pyridinylamino)-5-thiazolyl]methyl]amino]benzamide Chemical Properties
density 1.44±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
form Solid
pka13.70±0.20(Predicted)
color White to off-white
Safety Information
MSDS Information
N-Cyclopropyl-2,4-difluoro-5-[[[2-(2-pyridinylamino)-5-thiazolyl]methyl]amino]benzamide Usage And Synthesis
UsesBMS-605541 is a selective and orally active inhibitor of VEGFR-2 kinase with an IC50 value of 23 nM and Ki value of 49 nM. BMS-605541 inhibits the activity of Flk-1, VEGFR-1 and PDGFR-β with IC50 values of 40 nM, 400 nM and 200 nM, respectively. BMS-605541 can be used for cancer research[1].
in vivo

BMS-605541 (12.5-180 mg/kg; once a day or twice a day for 14 days) has anti-tumor activity in thymic mice subcutaneously implanted with L2987 and HCT-116 xenografts[1].
Pharmacokinetic (PK) parameters of BMS-605541[1]

SpeciesAdministration mannerDose (mg/kg)Cmax (μM)Tmax (h)AUC (μM h)T1/2 (h)MRT (h)Cl (mL/min kg)Vss (L/kg) Fpo (%)
MouseOral gavage901480.5649 (0-24 h)1.73.4100
MouseIntravenous injection1011.81.7100
RatOral gavage5044.02.02022.23.5100
RatIntravenous injection1013.61.1100
CynoOral gavage58.00.7528.57.17.952
CynoIntravenous injection13.91.652
IC 50VEGFR-2: 23 nM (IC50); VEGFR-2: 49 nM (Ki); Flk-1: 40 nM (IC50); VEGFR-1: 400 nM (IC50); PDGFR-β: 200 nM (IC50)
storageStore at -20°C
References[1] Borzilleri RM, et al. Discovery and evaluation of N-cyclopropyl- 2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5- ylmethyl)amino)benzamide (BMS-605541), a selective and orally efficacious inhibitor of vascular endothelial growth factor receptor-2. J Med Chem. 2006 Jun 29;49(13):3766-9. DOI:10.1021/jm060347y
N-Cyclopropyl-2,4-difluoro-5-[[[2-(2-pyridinylamino)-5-thiazolyl]methyl]amino]benzamide Preparation Products And Raw materials
Tag:N-Cyclopropyl-2,4-difluoro-5-[[[2-(2-pyridinylamino)-5-thiazolyl]methyl]amino]benzamide(639858-32-5) Related Product Information
  • HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
  • All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
    According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.
  • Copyright © 2023 ChemicalBook All rights reserved.