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| | ZT-12-037-01 Basic information |
| Product Name: | ZT-12-037-01 | | Synonyms: | ZT-12-037-01;2,4-Quinazolinediamine, N2-cyclopropyl-6,7-dimethoxy-N4-[1-(1-methylethyl)-4-piperidinyl]-;inhibit,ZT 12 037 01,ZT1203701,Ras,Inhibitor;N2-Cyclopropyl-N4-(1-isopropylpiperidin-4-yl)-6,7-dimethoxyquinazoline-2,4-diamine | | CAS: | 2328073-61-4 | | MF: | C21H31N5O2 | | MW: | 385.5 | | EINECS: | | | Product Categories: | | | Mol File: | 2328073-61-4.mol |  |
| | ZT-12-037-01 Chemical Properties |
| storage temp. | 2-8°C(protect from light) | | solubility | DMSO: 8.33 mg/mL (21.61 mM) |
| | ZT-12-037-01 Usage And Synthesis |
| Biological Activity | ZT-12-037-01 is an ATP-competitive STK19 inhibitor with IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N), respectively. At a concentration of 1 μM, it is highly selective against a kinase library of 468 kinases. | | in vitro | Treatment with ZT-12-037-01 could effectively inhibit NRAS phosphorylation. ZT-12-037-01 is an ATP-competitive inhibitor that potently inhibits melanocytic colony formation, proliferation and tumor formation driven by mutant NRAS-STK19. It's pro-apoptotic activity was significantly enhanced in cells expressing oncogenic NRAS. | | in vivo | ZT-12-037-01 is a potent STK19 inhibitor with low toxicity in vivo. In the SK-MEL-2 xenograft model (carrying NRAS. | | target | | Target | Value | STK19
(Cell-free assay) | 23.96 nM | STK19 (D89N)
(Cell-free assay) | 27.94 nM | < /table>
| | ZT-12-037-01 Preparation Products And Raw materials |
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Tag:ZT-12-037-01(2328073-61-4)
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