2-庚基-4-羟基喹啉-N-氧化物
| 中文名称 | 2-庚基-4-羟基喹啉-N-氧化物 |
|---|---|
| 中文同义词 | 2-庚基-4-羟基喹啉1-氧化物;2-N-庚基-4-羟基喹啉N-氧化物 |
| 英文名称 | 2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE |
| 英文同义词 | 2-(n-heptyl)-4-hydroxyquinolinen-oxide;2-heptyl-4-quinolino1-oxide;kf8940;2-Heptylquinolin-4-ol 1-oxide;Antibiotic KF-8940;Pyo II;C04284;NZPACTGCRWDXCJ-UHFFFAOYSA-N |
| CAS号 | 341-88-8 |
| 分子式 | C16H21NO2 |
| 分子量 | 259.34 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 341-88-8.mol |
| 结构式 |  |
2-庚基-4-羟基喹啉-N-氧化物 性质
| 熔点 | 156-157° |
|---|---|
| 沸点 | 445.8±37.0 °C(Predicted) |
| 密度 | 1.09±0.1 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,2-8°C |
| 溶解度 | 可溶于 DMSO（加热时高达 8 mg/ml）或乙醇（加热时高达 13 mg/ml）。 |
| 酸度系数(pKa) | 1.07±0.40(Predicted) |
| 形态 | 白色至类白色结晶固体。 |
| 颜色 | 白色 |
| 稳定性 | 可在-20°下的DMSO或乙醇溶液保存长达1个月。 |
| Target | Value |
|
Complex III
(Cell-free assay) | 64 nM(Kd) |
|
NDH-2
(Cell-free assay) | 7.3 μM |
HQNO is a potent inhibitor of mitochondrial type II NADH:quinone oxidoreductase (NDH-2) in many species, including
Yarrowia lipolytica
,
S. cerevisiae
,
Gluconobacter oxydans
,
T. gondii
,
P. falciparum
, and
S. aureus
. HQNO targets the Q-site of NDH-2.
HQNO concentrations are varied from 0 to 100 μM and 0 to 300 μM for wild-type (WT) and I379E
C. thermarum
NDH-2 variant, respectively to determine IC
50
values. WT NDH-2 has an IC
50
value of 10.5±1.3 μM HQNO in the presence of 400 μM Menadione (MD). In the presence of 50 μM MD, the IC
50
value for HQNO decreases slightly to 7.3±1.2 μM and near complete inhibition (~15% residual activity) is observed with >50 μM HQNO. At 50 μM MD, HQNO inhibition is observed with an IC
50
value of 54.3±1.2 μM.
安全信息
| RTECS号 | VC5890000 |
|---|---|
| 毒性 | LD50 intraperitoneal in mouse: 40mg/kg |