尼日利亚菌素钠盐
中文名称 | 尼日利亚菌素钠盐 |
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中文同义词 | 尼日利亚菌素钠盐;尼日利亚菌素钠;NIGERICIN(钠盐形式);尼日利亚菌素钠盐, 来源于吸水链霉菌;尼日利亚菌素钠盐,来源于链霉菌,吸湿性菌;尼日利亚菌素钠 NIGERICIN SODIUM SALT;尼日利亚菌素,钠盐, 吸水链霉菌;尼日利亚霉素(钠盐) |
英文名称 | Nigericin sodium salt |
英文同义词 | Polyetherin A, Azalomycin M, Helixin C, Antibiotic K178, Antibiotic X-464;Antibiotic K178, Antibiotic X464, Azalomycin M, Helexin C, Polyetherin A;Sodium (2R)-2-[(3S,6R)-6-[[(2S,4R,5R,7R,9R,10R)-2-[(5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl]methyl]-3-methyloxan-2-yl]propanoate;Nigericin, monosodium salt;Nsc292567;Nigericin sodium salt,Antibiotic K178, Antibiotic X464, Azalomycin M, Helexin C, Polyetherin A;Nigericin sodiuM sa;Polyetherin A, AzaloMycin M, Helixin C, K 178, X 464, Pandavir |
CAS号 | 28643-80-3 |
分子式 | C40H69NaO11 |
分子量 | 748.97 |
EINECS号 | 608-231-4 |
相关类别 | 微生物代谢物;抗生素;聚醚类抗生素;抗生素及抗病毒;生化试剂;原料药;试剂盒-细胞分析试剂盒;API |
Mol文件 | 28643-80-3.mol |
结构式 |
尼日利亚菌素钠盐 性质
熔点 | approximate 255℃ |
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储存条件 | 2-8°C |
溶解度 | 溶于氯仿、甲醇或乙醇 |
形态 | 溶液在储存期间颜色可能会变暗 |
颜色 | 白色 |
Merck | 13,6569 |
BRN | 3892398 |
稳定性 | 可在-20°下的DMSO或乙醇溶液保存长达2个月。 |
InChIKey | MOYOTUKECQMGHE-NTQCAYBPSA-M |
LogP | 4.817 (est) |
Target | Value |
Potassium channel
() | |
Hydrogen channel
() | |
Pb 2+
() | |
NLRP3
() |
Nigericin (0.1 µM) decreases inhibits proliferation and clonogenicity of H460 lung cancer cells in a dose dependent manner. Nigericin inhibits migration and invasion of H460 lung cancer cells. Nigericin (0.1-10 nM) has apparently a dual effect on cell volume, that is a shrinking effect at lower Nigericin concentrations and a swelling effect at higher concentrations. Nigericin (0.1-1 nM) significantly decreases cytosolic pH (pHi), and slightly increases the pHi at 5 and 10 nM. Nigericin exhibits higher toxicity on S18 cells than S26 cells, with IC 50 of 2.03±0.55 μM and 4.77±2.35 μM, respectively. Nigericin can selectively kill cancer stem cells in NPC in vitro. Nigericin dramatically reduces the migration ability of S18 and HONE-1 cells. Nigericin exhibits gteat toxicity for the HT29 and SW116 cell line with IC 50 of 12.92±0.25 μmol and 15.86±0.18 μmol. Nigericin also shows a decreased ability to form colonies under anchorage-independent conditions in a standard soft agar assay.
Ngericin (4 mg/kg, i.p.) significantly reduces tumor growth and acts synergistically with the chemotherapeutic agent DDP, as shown by the tumor volumes. Nigericin markedly decreases Bmi-1 in vivo. Overexpression of Bmi-1 partially restores CSC content and metastatic ability of NPC cells under Nigericin treatment. The downregulation of Bmi-1 may be involved in the inhibitory effect of Nigericin on CSCs in NPC.
安全信息
危险品标志 | T |
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危险类别码 | 25-36/37/38 |
安全说明 | 26-36/37/39-45 |
危险品运输编号 | UN 3462 6.1/PG 3 |
WGK Germany | 3 |
RTECS号 | QT6840000 |
危险等级 | 6.1 |
海关编码 | 29419090 |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | S6653 | 尼日利亚菌素钠盐 Nigericin sodium salt | 28643-80-3 | 5mg | 794.43元 |
2024/08/19 | HY-100381 | 尼日利亚菌素钠盐 Nigericin sodium salt | 28643-80-3 | 5mg | 900元 |