CINACALCET Suppliers list
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Products Intro: Product Name:CINACALCET
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: Shanghai Yingrui Biopharma Co., Ltd.
Tel: +86-21-33585366
Products Intro: Product Name:Cinacalcet
Purity:0.99 Package:100g;250g;500g;1kg
Company Name: career henan chemical co
Tel: +86-371-86658258
Products Intro: Product Name:CINACALCET
Purity:99% Package:3KG;33USD
Company Name: Biochempartner
Tel: 0086-13720134139
Products Intro: Product Name:Cinacalcet
Purity:98% HPLC LCMS Package:10G;20G
Company Name: Chemwill Asia Co.,Ltd.
Tel: 86-21-51086038
Products Intro: CAS:226256-56-0
Purity:99% Package:5KG;1KG;25KG PRICE quotation Remarks:Factory stock, quality assurance, price concessions

Lastest Price from CINACALCET manufacturers

  • US $33.00 / KG
  • 2019-07-10
  • CAS:226256-56-0
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 1000kg
CINACALCET Basic information
Synonyms:Sinacasse;[(1R)-1-(naphthalen-1-yl)ethyl]({3-[3-(trifluoroMethyl)phenyl]propyl})aMine;Cinacelcet HCl;(αR)-α-Methyl-N-[3-[3-(trifluoroMethyl)phenyl)propyl]-1-napthaleneMethanaMine;Cinacalcet(AMG 073);AMG 073 (Cinacalcet);CINACALCET;Cinacalcet (R-EnantioMer)
Product Categories:Mimpara, Sensipar;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:226256-56-0.mol
CINACALCET Chemical Properties
Boiling point 440.9±45.0 °C(Predicted)
density 1.154±0.06 g/cm3(Predicted)
storage temp. Refrigerator
CAS DataBase Reference226256-56-0(CAS DataBase Reference)
Safety Information
Hazardous Substances Data226256-56-0(Hazardous Substances Data)
MSDS Information
CINACALCET Usage And Synthesis
Mechanism Cinacalcet is a basic single-chain peptide hormone secreted by the parathyroid chief cells , called PTH, it is a blend of 84 amino acids,it has an effect of elevating serum calcium and lowing phosphorus, regulating calcium and phosphorus metabolism balance of vertebrate body . In parathyroid cells,the first main precursor of PTH is synthesized at first, it is called Prepro-parathyroid, containing 115 amino acids, the predecessor of the substance after cell lysis in the thyroid becomes the second precursor substance,it is called parathyroid-hormone containing 90 amino acids , the latter becomes polypeptide containing 84 amino acids by cleaving within the cell, that is PTH. Normal human plasma PTH concentration is about 1 ng/ml.
The main physiological function of parathyroid hormone is promoting osteolysis, bone calcium mobilization into the blood, increasing calcium, increasing vigor of serum and bone alkaline phosphatase ;it can inhibit renal tubular reabsorption of phosphate, promote urinary excretion of phosphorus , decrease phosphorus; PTH via activation of vitamin D3, indirectly promotes intestinal absorption of calcium, magnesium and phosphorus. PTH secretion is mainly affected by the regulation of calcium concentration. Blood Ca2 + elevates, PTH secretion reduces; blood Ca2 + decreases, secretion is increased. In addition, phosphorus increasing via reducing calcium stimulates the secretion of PTH, calcitonin massive release can also promote increasing secretion of PTH.
Serum parathyroid hormone except for the study of parathyroid disease, has a certain value on the differential diagnosis of hypercalcemia and hypocalcemia The main clinical significance is as follows:
1. Diagnosis of parathyroid disease. When there are hyperparathyroidism or ectopic PTH secretion disorder, PTH increases ; when there are hypoparathyroidism, parathyroid surgery or radiation damage, etc., PTH decreases.
2. Identification of hypercalcemia and hypocalcemia. When abnormal calcium is caused by calcium parathyroid disorders ,serum calcium lifts as serum PTH lifts, while abnormal blood calcium is caused by other causes , PTH does not change.
The above information is edited by the Chemicalbook of Tian Ye.
Chemical PropertiesYellow Oil
UsesCinacalcet is the first calcimimetic drug approved by the United States Food and Drug Administration for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease
Usesmacular degeneration therapy
UsesLabeled Cinacalcet, intended for use as an internal standard for the quantification of Cinacalcet by GC- or LC-mass spectrometry.
DefinitionChEBI: A secondary amino compound that is (1R)-1-(naphthalen-1-yl)ethanamine in which one of the hydrogens attached to the nitrogen is substituted by a 3-[3-(trifluoromethyl)phenyl]propyl group.
Brand nameSensipar (Amgen).
CINACALCET Preparation Products And Raw materials
Tag:CINACALCET(226256-56-0) Related Product Information
(S)-1-(naphthalen-1-yl)ethan-1-amine Cinacalcet Impurity 21 3-[o-(alpha,alpha,alpha-trifluorotolyl)]propionic acid ?-(+)-1-(1-NAPHTHYL)ETHYLAMINE HYDROCHLORIDE Cinacalcet IMpurity 3-(3-Trifluoromethylphenyl)propionic acid (R)-1-(5,6,7,8-tetrahydronaphthalen-1-yl)ethanamine hydrochloride (R)-N-(1-(7,8-dihydronaphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine (R)-1-(naphthalen-1-yl)ethan-1-amine (R)-N-(1-(naphthalen-1-yl)ethyl)-3-(4-(trifluoromethyl)phenyl)propan-1-amine hydrochloride 1-NaphthaleneMethanaMine, 7,8-dihydro-α-Methyl-N-[3-[3-(trifluoroMethyl)phenyl]propyl]-, hydrochloride (1:1), (αR)- 3-(3-METHYLPHENYL)PROPIONIC ACID Cinacalcet Impurity 20 (R)-1-(Naphthalen-2-yl)ethanamine hydrochloride 4-(TRIFLUOROMETHYL)HYDROCINNAMIC ACID Sevelamer hydrochloride Cinacalcet hydrochloride CINACALCET