| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:TK05;TK-05,TK05
CAS:1245734-61-5
Purity:98% Package:5 mg
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| Company Name: |
RD International Technology Co., Limited
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| Tel: |
18988968278 |
| Email: |
sales@ubiochem.com |
| Products Intro: |
Product Name:TK05
CAS:1245734-61-5
Purity:5mg;10mg;50mg;100mg;250mg;500mg;1g Package:5mg;10mg;50mg;100mg;250mg;500mg;1g
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| Product Name: | TK05 | | Synonyms: | TK05;TK-05,TK05;Benzoic acid, 5-[[5-[(4-chlorophenyl)(cyclopropylmethyl)amino]-2-pyridinyl]carbonyl]-2-(4-methoxybenzoyl)- | | CAS: | 1245734-61-5 | | MF: | C31H25ClN2O5 | | MW: | 540.99 | | EINECS: | | | Product Categories: | | | Mol File: | 1245734-61-5.mol |  |
| Boiling point | 769.1±60.0 °C(Predicted) | | density | 1.348±0.06 g/cm3(Predicted) | | pka | 2.56±0.36(Predicted) |
| Biological Activity | TK05 is a potent and selective inhibitor of leukotriene C4 synthase (LTC4S) with an IC50 of 95 nM[1].
TK05 reduces LTC4 production in a dose-dependent manner with an IC50 value of 318 ± 60 nM in MM6 Cells[1].
TK05 (0.12-6 mg/kg; given i.p.; only once) significantly reduces LTE4 levels[1]. | | References | [1]. Kleinschmidt TK, et al. Tandem Benzophenone Amino Pyridines, Potent and Selective Inhibitors of Human Leukotriene C4 Synthase. J Pharmacol Exp Ther. 2015 Oct;355(1):108-16. |
| | TK05 Preparation Products And Raw materials |
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