| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
|
| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:(±)-trans-GK563
CAS:2351820-19-2
Purity:>98% Package:1mg;10mg;50mg;100mg;
|
| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:(±)-trans-GK563
CAS:2351820-19-2
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:(±)-trans-GK563
CAS:2351820-19-2
Purity:94% Package:1mg;5mg;10mg
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.com |
| Products Intro: |
Product Name:GK563
CAS:2351820-19-2
Purity:详情请点击官网 Package:1 mg
|
|
| | (±)-trans-GK563 Basic information |
| | (±)-trans-GK563 Chemical Properties |
| Boiling point | 364.2±11.0 °C(Predicted) | | density | 1.010±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Chloroform: slightly soluble; DMSO: slightly soluble; Methanol: slightly soluble |
| | (±)-trans-GK563 Usage And Synthesis |
| Description | trans-(±)-GK563 is a potent β-lactone inhibitor of group VIA (GVIA) calcium-independent phospholipase A2 (GVIA iPLA2; IC50 = 1 nM).1 It is selective for GVIA iPLA2 over GVIA cPLA2 (IC50 = 22 μM). trans-(±)-GK563 (1 and 10 μM) inhibits apoptosis induced by IL-1β and IFN-γ in INS-1 β-cells. | | References | 1. Dedaki, C., Kokotou, M.G., Mouchlis, V.D., et al. β-Lactones: A novel class of Ca2+-independent phospholipase A2 (group VIA iPLA2) inhibitors with the ability to inhibit β-cell apoptosis J. Med. Chem. 62(6),2916-2927(2019). |
| | (±)-trans-GK563 Preparation Products And Raw materials |
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