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Sennoside A

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CAS:81-27-6
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CAS:81-27-6
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CAS:81-27-6
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CAS:81-27-6
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  • CAS:81-27-6
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Sennoside A Basic information
Product Name:Sennoside A
Synonyms:Sennoside A std.;SENNOSIDEA60%;SENNOSIDE A(P);SENNOSIDE A(SH);SENNOSIDA;CALCIUM SENNOSIDE 5%, 10%, 20%, 60%;[9,9'-Bianthracene]-2,2'-dicarboxylicacid,5,5'-bis(β-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-,(9R,9'R)-;Sennoside A1
CAS:81-27-6
MF:C42H38O20
MW:862.74
EINECS:201-339-9
Product Categories:The group of Sennosides;Anthraquinones, Hydroquinones and Quinones;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors
Mol File:81-27-6.mol
Sennoside A Structure
Sennoside A Chemical Properties
Melting point >191oC (dec.)
alpha D20 -164° (c = 0.1 in 60% acetone); D20 -147° (c = 0.1 in 70% acetone); D20 -24° (c = 0.2 in 70% dioxane)
Boiling point 1144.8±65.0 °C(Predicted)
density 1.743±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Aqueous Base (Slightly, Heated), DMSO (Slightly, Heated)
pka3.31±0.40(Predicted)
color Yellow to Dark Yellow
BRN 5723746
Stability:Hygroscopic
InChIKeyIPQVTOJGNYVQEO-KGFNBKMBSA-N
LogP1.880 (est)
Safety Information
Risk Statements 22
Safety Statements 22-45
WGK Germany 3
3-10
HS Code 29173990
MSDS Information
ProviderLanguage
SigmaAldrich English
Sennoside A Usage And Synthesis
Chemical PropertiesLight yellow powder
Usesa natural anthroquinonone glucoside calcium complex with laxative properties
UsesSennoside A is used as a laxative in the treatment of constipation. In addition. it is hypothesized to induce cell proliferation and may be a potential carcinogenic agent.
DefinitionChEBI: Sennoside A is a member of the class of sennosides that is rel-(9R,9'R)-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid which is substituted by hydroxy groups at positions 4 and 4', by beta-D-glucopyranosyloxy groups at positions 5 and 5', and by oxo groups at positions 10 and 10'. The exact stereochemisty at positions 9 and 9' is not known - it may be R,R (as shown) or S,S. It is a member of sennosides and an oxo dicarboxylic acid.
Purification MethodsSennoside A (bianthraquinonyl-bis-glucoside R,R-enantiomer) [81-27-6] M 862.7, m 220 -2 4 0o(dec), [ ] D -164o (c 0.1, Me2CO/H2O 6:4), [ ] D -24o (c 0.2, 70% aqueous dioxane). Sennoside A forms yellow crystals from aqueous acetone, 2-ethoxyethanol or large volumes of H2O. [Stoll et al. Helv Chim Acta 32 1896 1900, Beilstein 17 III/IV 3403.]
Sennoside A Preparation Products And Raw materials
Tag:Sennoside A(81-27-6) Related Product Information
Sennoside C,Sennoside C Sennoside D,Sennoside D Sennoside B SENNIDINE A 2,2'-DIHYDROXYBENZOPHENONE 4-FORMYL-3-HYDROXYBENZOIC ACID 4-Acetylbenzoic acid 5-ISOPROPYL-3-METHYLPHENOL 4-BROMOBENZHYDROL BIANTHRONYL 4-ETHYL-3-HYDROXYBENZOIC ACID 1,1,2,2-TETRAPHENYLETHANE SENNOSIDE,SENNOSIDE A AND B,SENNOSIDE A AND B,SENNOSIDE 3-Hydroxy-4-methylbenzoic acid HELICIN SENNOSIDES 3-HYDROXY-5-METHYL-BENZOIC ACID 3-ISOBUTYL-BENZOIC ACID