- GRAMICIDIN A USP/EP/BP
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- $1.10 / 1g
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2021-07-20
- CAS:11029-61-1
- Min. Order: 1g
- Purity: 99.9%
- Supply Ability: 100 Tons Min
- Gramicidin A
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- $0.01 / 1KG
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2020-05-13
- CAS:11029-61-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 50 tons
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| | GRAMICIDIN A Basic information |
| | GRAMICIDIN A Chemical Properties |
| storage temp. | 2-8°C | | solubility | ethanol: soluble | | form | White to off-white solid | | color | colorless or white | | BRN | 6461131 |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 | | RTECS | MD8230000 | | Toxicity | mouse,LD50,intraperitoneal,60mg/kg (60mg/kg),"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 4(1), Pg. 240, 1980. |
| | GRAMICIDIN A Usage And Synthesis |
| Uses | Gramicidin A is an effective antibiotic against Gram positive organisms. | | Purification Methods | Purify gramicidin A by countercurrent distribution from *C6H6/CHCl3, MeOH/H2O (15:15:23:7) with 5000 tubes. Fractions are examined by UV (280nm) of small aliquots. Separation from gramicidin C and other material occurred after 999 transfers. [Gross & Witkop Biochemistry 4 2495 1965, Bauer et al. Biochemistry 11 3266 1972.] Purify it finally by recrystallisation from EtOH/H2O and dry it at 100o/10-2mm over KOH. It forms platelets m 229-230o. It is almost insoluble in H2O (0.6%) but soluble in lower alcohols, dry Me2CO, dioxane, acetic acid and pyridine. The commercial material is more difficult to crystallise than the synthetic compound. [Sarges & Witkop J Am Chem Soc 86 1861 1964, 87 2011, 2020 1965.] It has characteristic [] D20 +27.3o (c 1.3, MeOH) and UV max at 282nm ( 22,100). The N-carbamoyldeformyl gramicidine A precipitates from EtOAc/pet ether (b 40-60o). [Beilstein 26 III/IV 4273.] |
| | GRAMICIDIN A Preparation Products And Raw materials |
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