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Company Name: Shanghai Bojing Chemical Co.,Ltd.
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Products Intro: Product Name:Cupferron
Purity:98% Package:25kg/ Drum
Company Name: TopScience Biochemical
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Company Name: Shanghai Zheyan Biotech Co., Ltd.
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Products Intro: Product Name:Cupferron
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Company Name: career henan chemical co
Tel: +86-371-86658258
Products Intro: Product Name:Cupferron
Purity:98% Package:1ASSAYS;1USD
Company Name: Haihang Industry Co.,Ltd
Tel: 86-531-88032799
Products Intro: CAS:135-20-6

Lastest Price from Cupferron manufacturers

  • Cupferron
  • US $1.00 / ASSAYS
  • 2019-07-10
  • CAS:135-20-6
  • Min. Order: 1ASSAYS
  • Purity: 98%
  • Supply Ability: 1kg,2kg,100kg
Cupferron Basic information
Analysis reagents Purification method Chemical properties Uses Production method Category Toxicity grading Acute toxicity Irritation data Explosive hazardous properties Flammability hazard characteristics Storage characteristics Extinguishing agent
Product Name:Cupferron
Synonyms:Cupferron, 97+%;CUPFERRON,REAGENT,ACS;Ammonium N-nitroso-N-phenylhydroxylamine;CUPEFERRON;Cupferron, 97% min;N-(Ammonium oxy)-N-nitrosophenylamine;N-Ammonium oxy-N-nitrosoaniline;N-Ammonium oxy-N-nitrosobenzenamine
Product Categories:
Mol File:135-20-6.mol
Cupferron Structure
Cupferron Chemical Properties
Melting point 150-155 °C (dec.)(lit.)
Boiling point 278.95°C (rough estimate)
density 1.3092 (rough estimate)
refractive index 1.6500 (estimate)
storage temp. 2-8°C
solubility well soluble in water and ethanol.
form Powder
color Needles from water
Water Solubility <0.1 g/100 mL at 18.5 ºC
Merck 14,2622
BRN 3919107
Stability:Stable, but may be moisture sensitive. Incompatible with strong oxidizing agents, strong bases, strong acids.
CAS DataBase Reference135-20-6(CAS DataBase Reference)
IARC2B (Vol. 127)
NIST Chemistry ReferenceCupferron(135-20-6)
EPA Substance Registry SystemCupferron (135-20-6)
Safety Information
Hazard Codes T
Risk Statements 25-36/37/38-40-45-43-23/24/25
Safety Statements 26-36/37-45-53
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS NC4725000
HazardClass 6.1
PackingGroup III
HS Code 29299090
Hazardous Substances Data135-20-6(Hazardous Substances Data)
ToxicityTDLo orl-rat: 123 g/kg/78W-C:CAR NCITR* NCI-CGTR-100,78
MSDS Information
SigmaAldrich English
ACROS English
ALFA English
Cupferron Usage And Synthesis
Analysis reagentsCupferron is an important analytical reagent, as Ammonium salt of N-nitroso hydroxylamine, commonly known as cupferron. It is usually white or light yellow bright flake scrystal, with sweet odour, long home to darken due to slow decomposition, but in fact can also be used in the analysis. It is soluble in water, benzene, alcohol, ether. The reagent is thermally decomposed to prepare nitrobenzene. Unstable in light and air, we need to save itin a brown reagent grinding mouth bottle, usually place a small amount of ammonium carbonate in bottle packaged with paper or cloth good as a preservative, store in a sealed dark cool place. It can be used as a precipitating agent and solvent extraction agent of copper, iron, tin, titanium, vanadium, chromium and other elements, as a masking agent for the determination of rare earth.
Nitrobenzene is reduced with zinc powder in an aqueous solution of ammonium chloride to get phenylhydroxylamine, which is then dissolved in ether, lead to excessive ammonia, and addn-butyl nitrite, then get cupferron, can form a stable five-membered ring chelate with metal ions, therefore, it is common organic precipitant. It can quantitatively measure Fe3 + ions in the acid solution, can also be measure Cu2 +, Sn4 +, Ti4 +, Ga3 +, Hf4 +and other ions, and vanadate (VO-3, VO3-3). When Fe3 +, Cu2 + ions mixedwith other metal ions together, the reagent can be used to separate them out. It is a chelating extractant for Al3 +, Au3 +, Be2 +, Co2 +, La3 +, Pu4 + and other ions, a masking agent for rare earth metal ions.
The above information is edited by the chemicalbook of Yan Yanyong.
Purification methodDdd 30g powdered crude into 120ml60 ℃ water, make it all dissolved, add 2g of powdered activated carbon and stir for 10~15min, filtrate with the calcined Buchner, and cool the filtrate to 10~15 ℃, then cool to 0 ℃ overnight. Suction filtration by using a glass filter to precipitate crystals, wash with 10ml ethanol and then wash with 10ml of ether, and dry in air.
Cupferron can also be recrystallized with ethanol to purify.
Chemical propertiesIt is white or cream colored flaky crystals. Melting point is 163-164 ℃, it is soluble in water and alcohol.
Uses1. Cupferron is used for quantitative analysis for aluminum, zinc, copper, iron, gallium, mercury, manganese, niobium, tin, tantalum, thorium, titanium, vanadium, zirconium and other elements
2. It is used as polymerization inhibitor, due to unique polymerization inhibition characteristics of cupferron, also the amount is small, can be used as an alternative of phenol polymerization inhibitor BHT, which is current largely applicated.
3. Cupferron is used for colorimetric determination for the weight of aluminum, bismuth, copper, iron, mercury, zinc, manganese, niobium, gallium, tantalum, thorium, titanium, vanadium, tin and other elements of. It is used for quantitative determination of iron in the strong acid solution, quantitative analysis of vanadate, separation of copper and iron together with the other metals, as a masking agent for measuring rare earths.
Production methodBenzene hydroxylamine ether solution was cooled in an ice bath, lead to an excess of ammonia, while stirring and continue adding the ammonia, solution of n-butyl nitrite was added for about 1h, then stir for 15min. Filter precipitate of cupferron, wash with diethyl ether, dry to get products. The product should be stored in a brown glass bottle, the bottle is placed a small amount of ammonium carbonate wrapped by paper (or cloth) as a stabilizer.
Toxicity gradinghighly toxic
Acute toxicityoral-rat LD 50: 199 mg/kg, intravenous-Mouse LD50: 180 mg/kg
Irritation dataEye-rabbit 20 mg/24 hours moderate
Explosive hazardous propertiesExplosive with thorium salt, zirconium salt or titanium salt solution at room temperature
Flammability hazard characteristicsIt produces toxic fumes of nitrogen oxides and ammonia at high temperature.
Storage characteristicsTreasury ventilation, low-temperature drying
Extinguishing agentDry powder, foam, sand, carbon dioxide, water mist
Chemical Propertieswhite to light yellow crystalline powder
Chemical PropertiesCupferron is a creamy-white crystalline compound
UsesAs a reagent for separating Sn from Zn, and Cu and Fe from other metals. Ppts iron quantitatively from strongly acid solution; as a quantitative reagent for vanadates with which it gives a dark-red ppt soluble in alkali solution, and for Ti with which it forms a yellow ppt; also suitable for the colorimetric estimation of Al.
UsesThe reagent used to be considered as specific for iron(II) and copper(II). However, in the course of later analytical studies it turned out that cupferron forms complexes with several other metals too, even in acidic medium. It is used today primarily for the determination of copper(II), but it has proved suitable for the determination of aluminium(III), bismuth(III), iron(III), mercury(II), thorium(IV), tin(IV), titanium(III), vanadium(IV) and zirconium(IV) as well. Of these, the zirconium(IV) complex is the most stable. Cupferron precipitates zirconium(IV) quantitatively from aqueous media containing sulfuric acid.
The reagent gives a precipitate with most of the above metal ions even in strong mineral acidic medium. Only the aluminium(III) complex does not precipitate in the presence of mineral acids.
By means of cupferron many metal ions can be separated: thus, for instance, iron(III) can be separated from aluminium(III) and manganese(II) and titanium (IV), zirconium(IV) and hafnium(IV) from many other metal ions, etc. Though the reagent makes possible several separations, the precipitates are not exactly of stoichiometric composition (they almost always contain some excess of the ligand). Hence instead of being directly weighed, the precipitates are usually ignited and the metal oxide residues weighed.
General DescriptionLight yellow or cream-colored crystals or a brown crystalline solid. As a reagent in the separation of copper and iron.
Air & Water ReactionsHygroscopic. Soluble in water.
Reactivity ProfileCupferron may be sensitive to prolonged exposure to air. Incompatible with strong oxidizing agents, strong acids and strong bases. Forms unstable solutions with thorium, titanium and zirconium salts.
Fire HazardFlash point data for Cupferron are not available; however, Cupferron is probably combustible.
Safety ProfileConfirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by intravenous route. An eye irritant. Solutions with thorium salts are unstable explosives above 15°C. Solutions with titanium or zirconium salts are unstable explosives above 40℃. When heated to decomposition it emits very toxic NH3 and NOx. See also N-NITROSO COMPOUNDS and AMINES
Potential ExposureCupferron is used to separate tin from zinc, and copper and iron from other metals in the laboratory. Cupferron also finds application as a quantitative reagent for vanadates and titanium; and for the colorimetric determination of aluminum. The potential for exposure appears to be greatest for those engaged in analytical or research studies involving use of the chemical. Workers may also be exposed to the compound during manufacturing processes.
CarcinogenicityCupferron is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
ShippingUN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Purification MethodsRecrystallise it twice from EtOH after treatment with Norite and finally once with EtOH. The crystals are washed with diethyl ether and air dried, then stored in the dark over solid ammonium carbonate. A standard solution (ca 0.05M prepared in air-free H2O) is prepared daily from this material for analytical work and is essentially 100% pure. [Olsen & Elving Anal Chem 26 1747 1954.] It can also be washed with Et2O, dried and stored as stated. In a sealed, dark container it can be stored for at least 12 months without deterioration. 260nm (CHCl3). max [Marvel Org Synth Coll Vol I 177 1941, Elving & Olson J Am Chem Soc 78 4206 1956, Beilstein 16 IV 891.] Possible CARCINOGEN.
IncompatibilitiesForms unstable and possibly explosive compounds with thorium salts; titanium, zirconium.
Cupferron Preparation Products And Raw materials
Raw materialsAmmonium carbonate-->1-Butyl nitrite-->N-Phenylhydroxylamine
Tag:Cupferron(135-20-6) Related Product Information
N-Nitroso-N-phenylhydroxylamine Cupferron 1,3-Dinitrobenzene Tiron Sodium diethyldithiocarbamate Ammonium citrate tribasic 2-Nitrochlorobenzene Ammonium hydroxide p-Nitrobenzoic acid Molybdic acid Sodium 3-nitrobenzenesulphonate Ammonium nitrate 3-Nitrochlorobenzene Nitrosobenzene Ammonium chloride Nitrobenzene Ammonium acetate AMMONIUM