| Company Name: |
Riedel-de Haen AG
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| Tel: |
800 558-9160 |
| Email: |
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| Products Intro: |
Product Name:Anti-phospho-Tyrosine Hydroxylase (pSer40) antibody produced in rabbit
Remarks:~1 mg/mL, affinity isolated antibody, buffered aqueous solution
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| Company Name: |
SIGMA-RBI
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| Tel: |
800 736 3690 (Orders) |
| Email: |
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| Products Intro: |
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| | ANTI-PHOSPHO-TYROSINE HYDROXYLASE (PSER40) Basic information |
| Product Name: | ANTI-PHOSPHO-TYROSINE HYDROXYLASE (PSER40) | | Synonyms: | ANTI-TYROSINE HYDROXYLASE (PSER40) RABBIT PAB;ANTI-PHOSPHO-TYROSINE HYDROXYLASE (PSER40);ANTI-RAT TYROSINE HYDROXYLASE, PHOSPHOSER 40;Anti-phospho-Tyrosine Hydroxylase (pSer40) antibody produced in rabbit;ANTI-TYROSINE HYDROXYLASE, RAT, PHOSPHO-SPECIFIC (SER40), RAT | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-PHOSPHO-TYROSINE HYDROXYLASE (PSER40) Structure]() |
| | ANTI-PHOSPHO-TYROSINE HYDROXYLASE (PSER40) Chemical Properties |
| storage temp. | −20°C | | form | aqueous glycerol solution |
| | ANTI-PHOSPHO-TYROSINE HYDROXYLASE (PSER40) Usage And Synthesis |
| General Description | Tyrosine Hydroxylase (TH) is encoded by the gene mapped to human chromosome 11p15.5, close to the insulin (INS) and Harvey-ras-1 (HRAS) genes. The N-terminal end of the protein plays a vital role in maintaining intracellular stability of the enzyme. tyrosine hydroxylase is expressed in various tissues such as brain, adrenal medulla and sympathetically innervated tissues. The enzyme is characterized with a regulatory domain (R), a catalytic domain (C) at N-terminal end, and a coiled-coil domain at the C-terminal end. | | Biochem/physiol Actions | Tyrosine Hydroxylase (TH) specifically catalyzes the hydroxylation of the amino acid L-tyrosine to 3, 4-dihydroxy-L-phenylalanine (L-DOPA). TH is a rate-limiting enzyme involved in the synthesis of catecholamine, involved in several brain functions, such as attention, memory, cognition, and emotion. Phosphorylation of the N-terminal portion of tyrosine hydroxylase controls the degradation of this enzyme by the ubiquitin-proteasome pathway. Alteration in the expression of the gene results in the pathogenesis of Parkinson′s disease (PD). Point mutation in the gene coding for TH leads to Segawa′s syndrome. |
| | ANTI-PHOSPHO-TYROSINE HYDROXYLASE (PSER40) Preparation Products And Raw materials |
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