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Trimethobenzamide

Trimethobenzamide Suppliers list
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 18871490254
Email: linda@hubeijusheng.com
Products Intro: Product Name:N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4,5-trimethoxybenzamide
CAS:138-56-7
Purity:99% Package:5KG;1KG Remarks:C21H28N2O5
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427
Email: sales@conier.com
Products Intro: Product Name:trimethobenzamide
CAS:138-56-7
Purity:0.99 Package:1kg
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel: +86-29-87569265 +86-18612256290
Email: 1056@dideu.com
Products Intro: Product Name:Trimethobenzamide
CAS:138-56-7
Purity:99% Package:1g;1USD|10g;1USD|100g;1USD|1KG;1USD|25KG;1USD
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: 0551-65418671
Email: sales@tnjchem.com
Products Intro: Product Name:trimethobenzamide
CAS:138-56-7
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel: +86-029-89586680 +86-18192503167
Email: 1026@dideu.com
Products Intro: Product Name:Trimethobenzamide USP/EP/BP
CAS:138-56-7
Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer

Trimethobenzamide manufacturers

  • Trimethobenzamide
  • Trimethobenzamide pictures
  • $1.00 / 1g
  • 2021-07-20
  • CAS:138-56-7
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 50tons
Trimethobenzamide Basic information
Product Name:Trimethobenzamide
Synonyms:4-(2-dimethylaminoethoxy)-n-(3,4,5-trimethoxybenzoyl)benzylamine;Benzamide, N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4,5-trimethoxy-;n-((4-(2-(dimethylamino)ethoxy)phenyl)methyl)-3,4,5-trimethoxy-benzamid;N-(4-[2-(Dimethylamino)ethoxy]benzyl)-3,4,5-trimethoxybenzamide;n-(p-(2-(dimethylamino)ethoxy)benzyl)-3,4,5-trimethoxy-benzamid;n-[(2-dimethylaminoethoxy)benzyl]-3,4,5-trimethoxybenzamide;N-[p-[2-(Dimethylamino)ethoxy]benzyl]-3,4,5-trimethoxybenzamide;TRIMETHOBENZAMIDE
CAS:138-56-7
MF:C21H28N2O5
MW:388.46
EINECS:205-332-1
Product Categories:
Mol File:138-56-7.mol
Trimethobenzamide Structure
Trimethobenzamide Chemical Properties
storage temp. 2-8°C
pkapKa 8.27±0.03(H2O) (Uncertain)
NIST Chemistry ReferenceBenzamide, n-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4,5-trimethoxy-(138-56-7)
Safety Information
Hazardous Substances Data138-56-7(Hazardous Substances Data)
MSDS Information
Trimethobenzamide Usage And Synthesis
OriginatorTigan,Beecham,US,1973
UsesAntiemetic.
DefinitionChEBI: The amide obtained by formal condensation of 3,4,5-trihydroxybenzoic acid with 4-[2-(N,N-dimethylamino)ethoxy]benzylamine. It is used to prevent nausea and vomitting in humans.
Manufacturing ProcessTo 122 grams (1 mol) of p-hydroxybenzaldehyde in 1 liter of chlorobenzene were added 66 grams (1.04 mols) of sodium methoxide (85%) and 108 grams (1 mol) of 2-dimethylaminoethyl chloride. The mixture was stirred and refluxed for 15 hours, then cooled and the precipitated sodium chloride filtered off. The filtrate was concentrated at steam temperature under water vacuum and the residual oil was fractionated in high vacuum, to give 4-(2- dimethylaminoethoxy)benzaldehyde, BP2.2145°C.
Two teaspoons of Raney nickel catalyst were added to a solution of 65.6 grams (0.34 mol) of 4-(2-dimethylaminoethoxy)benzaldehyde in 300 ml of 10% ammoniacal ethanol. The mixture was hydrogenated at 80°C and a pressure of 1,000 psi. The catalyst was filtered off, the volatiles were distilled off and the residual oil was fractionated in high vacuum, to obtain 4-(2- dimethylaminoethoxy)benzylamine, BP0.3120° to 123°C.
To 9.7 grams (0.05 mol) of 4-(2-dimethylaminoethoxy)benzylamine, dissolved in 100 ml of acetonitrile, was added all at once 12 grams (0.051 mol) of 3,4,5-trimethoxybenzoyl chloride, dissolved in 75 ml of acetonitrile. The mixture was stirred and refluxed for 8 hours, and then cooled. The crystalline solid, which had formed, was filtered off, washed with acetonitrile and recrystallized from acetonitrile, to give 4-(2-dimethylaminoethoxy)-N-(3,4,5- trimethoxybenzoyl)benzylamine hydrochloride, MP 185° to 186°C.
Brand nameTigan (King).
Therapeutic FunctionAntinauseant
Tag:Trimethobenzamide(138-56-7) Related Product Information
Trimethoprim DIMETHYLAMINOPYRIDINE, POLYMER-BOUND Benzyl nicotinate Dibenzylamine 3-Dimethylaminopropylamine Benzyl benzoate Benzyl alcohol Benzyl chloride Benzyl isocyanate Phenoxybenzamine hydrochloride Dimethylcarbamoyl chloride N,N-Dimethyl-1,4-phenylenediamine 4-Fluorobenzylamine Benzyl TRIMETHOBENZAMIDE HYDROCHLORIDE,Trimethobenzamide HCL 4-[2-(DIMETHYLAMINO)ETHOXY]BENZYLAMINE Itopride Ethoxy