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1,3-Dioxolane

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CAS:646-06-0
Purity:99% Package:26/KG
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CAS:646-06-0
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CAS:646-06-0
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Products Intro: Product Name:1,3-dioxolane
CAS:646-06-0
Purity:99.9%

Lastest Price from 1,3-Dioxolane manufacturers

  • 1,3-Dioxolane
  • US $1.00 / KG
  • 2018-08-07
  • CAS:646-06-0
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: Customized
1,3-Dioxolane Basic information
Product Name:1,3-Dioxolane
Synonyms:1,3-Dioxolane, stabilized, 99.5%;1,3-Dioxolane, stabilized, 99+%;cis-2-(2,4-Dichlorophenyl)-2-(1H-imidazole-1yl-methyl-4-(p-toluensulfonyl)oxymethyl-1,3-dioxolane;1,3-Dioxolane (stabilized with Triethylamine);1,3-Dioxolane, 99.5%, stabilized;1,3-Dioxolane, stabilized;dihydro-1,3-dioxole;Ethylene methylene ether
CAS:646-06-0
MF:C3H6O2
MW:74.08
EINECS:211-463-5
Product Categories:Dioxanes & Dioxolanes;Dioxolanes;Intermediates & Fine Chemicals;Pharmaceuticals;Alternative Energy;Anhydrous Solvents;Electrolytes;Materials Science;Organic Solvents;Solvent Bottles;Solvent by Application;Solvent Packaging Options;Solvents;Sure/Seal Bottles;ReagentPlus Solvent Grade Products;ACS and Reagent Grade Solvents;Amber Glass Bottles;ReagentPlus
Mol File:646-06-0.mol
1,3-Dioxolane Structure
1,3-Dioxolane Chemical Properties
Melting point −95 °C(lit.)
Boiling point 74-75 °F(lit.)
density 1.06 g/mL at 25 °C(lit.)
vapor density 2.6 (vs air)
vapor pressure 70 mm Hg ( 20 °C)
refractive index n20/D 1.401(lit.)
Fp 35 °F
storage temp. Refrigerator
solubility 1000g/l soluble
form Liquid
color White to off-white
explosive limit2.1-20.5%(V)
Water Solubility SOLUBLE
BRN 102453
Stability:Below 4°C
CAS DataBase Reference646-06-0(CAS DataBase Reference)
NIST Chemistry Reference1,3-Dioxolane(646-06-0)
EPA Substance Registry System1,3-Dioxolane(646-06-0)
Safety Information
Hazard Codes F
Risk Statements 11
Safety Statements 16
RIDADR UN 1166 3/PG 2
WGK Germany 1
RTECS JH6760000
Autoignition Temperature525 °F
TSCA Yes
HazardClass 3
PackingGroup II
HS Code 29329970
Hazardous Substances Data646-06-0(Hazardous Substances Data)
ToxicityLD50 orally in Rabbit: 3000 mg/kg LD50 dermal Rabbit 9074 mg/kg
MSDS Information
ProviderLanguage
Ethylene glycol methylene ether English
SigmaAldrich English
ACROS English
ALFA English
1,3-Dioxolane Usage And Synthesis
Chemical PropertiesColourless Liquid
Uses1,3-Dioxolane is an intermediate for the preparation of Acyclovir (A192400). Also, 1,3-Dioxolane is used in the synthesis of new Vandetanib (V097100) analogs.
UsesIntermediate for the preparation of Acyclovir-d4
DefinitionChEBI: A cyclic acetal that is pentane in which the carbon atoms at positions 1 and 3 are replaced by oxygen atoms respectively.
General DescriptionA clear colorless liquid. Flash point 35°F. Slightly denser than water. Vapors heavier than air.
Air & Water ReactionsHighly flammable. When exposed to air 1,3-Dioxolane undergoes autooxidation with formation of peroxides. In the distillation process peroxides will concentrate causing violent explosion. Soluble in water.
Reactivity ProfileEthers, such as 1,3-Dioxolane, can act as bases. They form salts with strong acids and addition complexes with Lewis acids. The complex between diethyl ether and boron trifluoride is an example. Ethers may react violently with strong oxidizing agents. In other reactions, which typically involve the breaking of the carbon-oxygen bond, ethers are relatively inert.
Health HazardInhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control may cause pollution.
Fire HazardHIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Safety ProfileModerately toxic by ingestion and intraperitoneal routes. Mildly toxic by skin contact and inhalation. A shin and severe eye irritant. Mutation data reported. A very dangerous fire hazard when exposed to heat or flame; can react with oxidizers. Used in lithium batteries. Potentially explosive reaction with lithium perchlorate. When heated to decomposition it emits acrid smoke and irritating fumes.
Purification MethodsDry it with solid NaOH, KOH or CaSO4, and distil it from sodium or sodium amalgam. Barker et al. [J Chem Soc 802 1959] heated 34mL of dioxalane under reflux with 3g of PbO2 for 2hours, then cooled and filtered. After adding xylene (40mL) and PbO2 (2g) to the filtrate, the mixture is fractionally distilled. Addition of xylene (20mL) and sodium wire to the main fraction (b 70-71o) led to a vigorous reaction, following which the mixture was again fractionally distilled. Xylene and sodium additions are made to the main fraction (b 73-74o) before it is finally distilled. [Beilstein 19/1 V 6.]
Tag:1,3-Dioxolane(646-06-0) Related Product Information
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