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| Product Name: | MSA-2 | | Synonyms: | 4-(5,6-Dimethoxybenzo[b]thiophen-2-yl)-4-oxobutanoic acid;Benzo[b]thiophene-2-butanoic acid, 5,6-dimethoxy-γ-oxo-;MSA-2;5,6-Dimethoxy-γ-oxobenzo[b]thiophene-2-butanoic acid;interferon-β,Inhibitor,TMEM173,ERIS,MPYS,immunity,secretion,tumor,Stimulator of Interferon Genes,MSA 2,MC38,STING,MSA2,TNF-α,MITA,MSA-2,inhibit;4- (5,6-Dimethoxybenzo [b] thiophen-2-yl) -4-oxobutyric acid | | CAS: | 129425-81-6 | | MF: | C14H14O5S | | MW: | 294.32 | | EINECS: | | | Product Categories: | | | Mol File: | 129425-81-6.mol |  |
| | MSA-2 Chemical Properties |
| Boiling point | 509.3±50.0 °C(Predicted) | | density | 1.336±0.06 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | DMSO: 125 mg/mL (424.71 mM) | | form | A crystalline solid | | pka | 4.35±0.17(Predicted) |
| | MSA-2 Usage And Synthesis |
| Description | MSA-2 was identified in a phenotypic screen for a chemical inducer of interferon beta secretion. In cell-free assays, MSA-2 binds to human and mouse STING. In tumor-bearing mice, MSA-2 induced elevated interferon-beta in plasma and tumors through two routes of administration. | | Uses | MSA-2 is an oral non-nucleotide STING agonist with EC50 of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. | | storage | Store at -20°C |
| | MSA-2 Preparation Products And Raw materials |
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