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| | 3-Chlorobenzophenone Basic information |
| | 3-Chlorobenzophenone Chemical Properties |
| Melting point | 85-87 °C(lit.) | | Boiling point | 332°C(lit.) | | density | 1.1459 (rough estimate) | | refractive index | 1.5260 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | form | powder to crystal | | color | White to Almost white | | BRN | 1869822 | | InChI | InChI=1S/C13H9ClO/c14-12-8-4-7-11(9-12)13(15)10-5-2-1-3-6-10/h1-9H | | InChIKey | CPLWKNRPZVNELG-UHFFFAOYSA-N | | SMILES | C(C1=CC=CC(Cl)=C1)(C1=CC=CC=C1)=O | | CAS DataBase Reference | 1016-78-0(CAS DataBase Reference) | | NIST Chemistry Reference | Methanone, (3-chlorophenyl)phenyl-(1016-78-0) | | EPA Substance Registry System | 3-Chlorobenzophenone (1016-78-0) |
| | 3-Chlorobenzophenone Usage And Synthesis |
| Chemical Properties | WHITE TO OFF-WHITE AMORPHOUS POWDER | | Uses | 3-Chlorobenzophenone is a reagent in the preparation of pharmaceuticals such as antitumor kinesin spindle protein inhibitors. | | Research | Li et al. research the influence of the chloro substituent position on the triplet reactivity of benzophenone derivatives. The 3-chlorobenzophenone (3-Cl-BP), 4-chlorobenzophenone (4-Cl-BP), and 4,4′-dichlorobenzophenone (4,4′-dichloro-BP) triplets exhibit similar hydrogen abstraction ability as has been found previously for the parent BP triplet. In IPA, the 3-Cl-DPK, 4-Cl-DPK, and 4,4′-dichloro-DPK radicals were observed and reacted with DMK radical, most likely at the para-position to form a para-LAT. In a MeCN: H2O/1:1 aqueous solvent, these DPK radicals were also observed but with a slower formation rate. All of these results indicate that the 2-chloro substituent reduces the hydrogen abstraction ability of the substituted BP triplet, not as may be expected that an electron-withdrawing group could increase its photoreduction activity[1].
| | References | [1] Wen Li. “Influence of the chloro substituent position on the triplet reactivity of benzophenone derivatives: a time-resolved resonance Raman and density functional theory study.” Journal of Raman Spectroscopy 43 6 (2011): 774–780.
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| | 3-Chlorobenzophenone Preparation Products And Raw materials |
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