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Ergosterol Suppliers list
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Products Intro: CAS:57-87-4
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: 008615858145714
Products Intro: Product Name:Ganoderma lucidum Polysaccharide
Purity:as in COA Package:as customers' requirements
Tel: +86 21 5161 9050/ 5187 7795
Products Intro: Product Name:Ergosterol
Purity:98% HPLC Package:5G;10G;25G;50G;100G;250G;1KG
Company Name: Shanghai Zheyan Biotech Co., Ltd.
Tel: 18017610038
Products Intro: Product Name:Ergosterol
Purity:HPLC>=98% Package:20mg/100mg
Company Name: career henan chemical co
Tel: +86-371-86658258
Products Intro: Product Name:Ergosterol
Purity:99% Package:1KG;1USD

Ergosterol manufacturers

  • Ergosterol
  • $0.00 / KG
  • 2021-12-03
  • CAS:57-87-4
  • Min. Order: 100g
  • Purity: 98%+
  • Supply Ability: 100kg
  • Ergosterol
  • $10.00 / Kg/Bag
  • 2021-11-02
  • CAS:57-87-4
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 20 Tons
  • Ergosterol
  • $1.00 / KG
  • 2021-09-29
  • CAS:57-87-4
  • Min. Order: 1KG
  • Purity: ≥97%
  • Supply Ability: 100kg/month
Ergosterol Basic information
Overview A target for antifungal drugs Reference
Product Name:Ergosterol
Synonyms:(22E)-Ergosta-5,7,22-trien-3-ol;(22E,24R)-Ergosta-5,7,22-trien-3-ol;(3beta)-Ergosta-5,7,22- trien-3-ol;ergosta-5:6,7:8,22:23-trien-3-ol;7,22-trien-3-ol, (3.beta.)-Ergosta-5 delta-5,7,22-ergostatrien-3beta-ol;Ergosterol (22E)-Ergosta-5,7,22-trien-3β-ol;Ergosterol hydrate, 96% (dry wt.), cont. up to ca 6% water;3β-Hydroxy-5,7,22-ergostatriene, 5,7,22-Ergostatrien-3β-ol, Provitamin D2
Product Categories:Vitamins and derivatives;Biochemistry;Hydroxysteroids;Vitamins;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical Intermediates;Steroids;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;Antibiotic
Mol File:57-87-4.mol
Ergosterol Structure
Ergosterol Chemical Properties
Melting point 156-158 °C(lit.)
Boiling point 250 °C (1.3 mmHg)
alpha -120 º (c=1, CHC13)
density 0.9784 (rough estimate)
refractive index -112.5 ° (C=1, THF)
storage temp. -20°C
form Crystalline Powder or Crystalline Needles
color White to off-white
optical activity[α]20/D 120±10°, c = 1% in chloroform
Sensitive Light Sensitive
Merck 14,3659
BRN 2338604
Stability:Stable, but may be light or air sensitive. Incompatible with acids, strong oxidizing agents.
CAS DataBase Reference57-87-4(CAS DataBase Reference)
NIST Chemistry ReferenceErgosterol(57-87-4)
EPA Substance Registry SystemErgosta-5,7,22-trien-3-ol, (3.beta.,22E)- (57-87-4)
Safety Information
Hazard Codes T+,T,Xn
Risk Statements 28-48/20/22-40-38-25-67-36/38-22-20-63
Safety Statements 28-36/37-45-26
RIDADR UN 2811 6.1/PG 2
WGK Germany 3
HazardClass 6.1
PackingGroup II
HS Code 29334900
Hazardous Substances Data57-87-4(Hazardous Substances Data)
MSDS Information
Provitamine D2 English
SigmaAldrich English
ACROS English
ALFA English
Ergosterol Usage And Synthesis

Sterols are essential structural and regulatory components of eukaryotic cell membranes. Mammals, plants and fungi produce similar sterols, which differ in the number and location of double bonds and methyl side chains. Ergosterol (ergosta-5, 7, 22-trien-3β-ol) is a sterol found in fungi, and named for ergot, the common name of members of the fungal genus Claviceps from which ergosterol was first isolated. Ergosterol is the end product of the sterol biosynthetic pathway and is the major sterol in yeasts. Like cholesterol in mammalian cells, it is responsible for membrane fluidity and permeability[6]. Ergosterol is a very important component of yeast and other fungal cell membranes, playing many important roles as that cholesterol plays in animal cells.[1] Its specificity in higher fungi is thought to be related to the climatic instabilities (highly varying humidity and moisture conditions) encountered by these organisms in their typical ecological niches (plant and animal surfaces, soil). Thus, despite the added energy requirements of ergosterol synthesis (if compared to cholesterol), ergosterol is thought to have evolved as a nearly ubiquitous, evolutionarily advantageous fungal alternative to cholesterol.

Figure 1 the chemical structure of ergosterol

A target for antifungal drugs

Since ergosterol is a key component in cell membranes of fungi, yet absent in those of animals. It has become a very useful target for antifungal drugs. Ergosterol is also present in the cell membranes of some protists, such as trypanosomes. This also becomes the basis for the use of some antifungals against West African sleeping sickness.
Antifungal drugs targeting ergosterol includes Amphotericin B[2, 3], fluconazole, miconazole, itraconazole, and clotrimazole. Amphotericin B acts by binding to sterols (ergosterol) in the cell membrane of susceptible fungi[2, 3]. This creates a transmembrane channel, and the resultant change in membrane permeability allowing leakage of intracellular components. Ergosterol, the principal sterol in the fungal cytoplasmic membrane, is the target site of action of amphotericin B and the azoles. Amphotericin B, a polyene, binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death[2, 3]. Amphotericin B, though has been replaced by safer agents in most circumstances, is still used, despite its side effects, for life-threatening fungal or protozoan infections.
Fluconazole, miconazole, itraconazole, and clotrimazole work in a different way, take effect through inhibiting synthesis of ergosterol from lanosterol by interfering with14α-demethylase[4, 5]. Fluconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Fluconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.

  1. Ruzicka, S., Edgerton, D., Norman, M., & Hill, T. (2000). The utility of ergosterol as a bioindicator of fungi in temperate soils. Soil Biology & Biochemistry, 32(7), 989-1005.
  2. Vertut-Croquin, A, et al. "Differences in the interaction of the polyene antibiotic amphotericin B with cholesterolor ergosterol-containing phospholipid vesicles. A circular dichroism and permeability study." Biochemistry 22.12(1983): 2939-44.
  3. Baginski, M, H. Resat, and E. Borowski. "Comparative molecular dynamics simulations of amphotericin B-cholesterol/ergosterol membrane channels." Biochim Biophys Acta 1567.1-2(2002): 63-78.
  4. Ballard, S. A., et al. "A novel method for studying ergosterol biosynthesis by a cell-free preparation of Aspergillus fumigatus and its inhibition by azole antifungal agents." J Med Vet Mycol 28.4(1990):335-344.
  5. Lv, Quan-Zhen; Yan, Lan; Jiang, Yuan-Ying (2016). "The synthesis, regulation, and functions of sterols in Candida albicans: Well-known but still lots to learn". Virulence. 7 (6): 649–659.
  6. Parks, L. W., Smith, S. J. & Crowley, J. H. (1995). Biochemical and physiological effects of sterol alterations in yeast – a review. Lipids 30, 227–230.
DescriptionErgosterol is a membrane component and with few exceptions is restricted to eumycotic fungi (101). As a constituent of intact membranes, its abundance should reflect the amount of living fungal biomass in an environment. This membrane component has been related to biomass by a number of investigators and the values range from 1.9 to 11.5 mg ergosterol g?1 mycelium (102). These conversion factors yield very high values for fungal biomass, and seem unrealistic (102) when compared with independent measures of bacterial biomass. It is likely that the ergosterol assay detects nonliving hyphae and these measures may overestimate viable fungal biomass. Similarly, chitin is a dominant cell wall component in most fungi and has been proposed as a unique marker for total fungal biomass.
Chemical Propertiessolid
UsesMost important of the provitamins D. Usually obtained from yeast which synthesizes it from simple sugars such as glucose. Vitamin (antirachitic).
UsesErgosterol is a steroid alcohol that when irradiated with ultraviolet light yields calciferol (vitamin d2). irradiated ergosterol is added to milk for vitamin d fortification.
Definitionergosterol: A sterol occurring infungi, bacteria, algae, and plants. It isconverted into vitamin D2 by the actionof ultraviolet light.
DefinitionChEBI: A phytosterol consisting of ergostane having double bonds at the 5,6-, 7,8- and 22,23-positions as well as a 3beta-hydroxy group.
HazardDue to its ability to catalyze calcium deposition in the bony structure (thus preventing rickets), overdosage of vitamin D may be harmful.
Purification MethodsCrystallise ergosterol from EtOAc, then from ethylene dichloride or EtOH/*C6H6 (3:1). It has been purified by conversion to the isobutyl ester which crystallises from Et2O/Me2CO (1:3) with m: turbid at 148o, melts at 159o and becomes clear at 162o, followed by hydrolysis, [Bill & Honeywell J Biol Chem 80 15 1938]. When crystallised from EtOH, it forms the 1.5-hydrate m 168o. The water is difficult to remove giving an amorphous solid m 166-183o, b 250o/high vacuum. It is light sensitive. The benzoate has m 169-171o, after crystallisation from Me2CO/*C6H6 (4:1) after prolonged standing at 0o and becomes highly charged, with [] D20 -177o (c 1, CHCl3). [UV of sterols: Hogness et al. J Biol Chem 120 239 1937, Beilstein 6 IV 4407.]
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