| Company Name: |
|
| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:NF 449;4,4',4'',4'''-[Carbonylbis(iMino-5,1,3-benzenetriyl-bis(carbonyliMino))]tetrakis-1,3-benzenedisulfonicacid,octasodiuMsalt
CAS:389142-38-5
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
|
| Company Name: |
EMMX Biotechnology LLC
|
| Tel: |
888-539-0666 |
| Email: |
info@emmx.com |
| Products Intro: |
Product Name:NF 449
CAS:389142-38-5
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
|
| Company Name: |
Chunchuang (Wuhan) Technology Co., Ltd
|
| Tel: |
15727060112 |
| Email: |
yutianchun2007@126.com |
| Products Intro: |
Product Name:NF449
CAS:389142-38-5
Purity:97%~99% HPLC Package:1mg;1g;10g;100g;1Kg;10Kg;100Kg;1T
|
|
| Product Name: | NF449 | | Synonyms: | 4,4',4'',4'''-[CARBONYLBIS(IMINO-5,1,3-BENZENETRIYL-BIS(CARBONYLIMINO))]TETRAKIS-1,3-BENZENEDISULFONIC ACID, OCTASODIUM SALT;4,4',4'',4'''-[CARBONYL-BIS[IMINO-5,1,3-BENZENETRIYL BIS-(CARBONYL-IMINO)]]TETRAKIS(BENZENE-1,3-DISULFONIC ACID) OCTASODIUM SALT;4,4',4'',4'''-[CARBONYL-BIS[IMINO-5,1,3-BENZENETRIYL BIS-(CARBONYLIMINO)]]TETRAKIS-(BENZENE-1,3-DISULFONIC ACID, 8NA);NF449;NF449 OCTASODIUM SALT;4,4',4'',4'''-(Carbonylbis(imino-5,1,3-benzenetriyl-bis(carbonylimino)))tetrakis-1,3-benzenedisulfonicacid,octasodium;4,4μ,4,4μ-[Carbonylbis[imino-5,1,3-benzenetriyl bis(carbonyl-imino)]]tetrakis(benzene-1,3-disulfonic acid) octasodium salt;4,4',4'',4'''-[Carbonylbis(imino-5,1,3-benzenetriyl-bis(carbonylimino))]tetrakis-1,3-benzenedisulfonic acid octasodium salt | | CAS: | 389142-38-5 | | MF: | C41H32N6O29S8 | | MW: | 1329.24 | | EINECS: | | | Product Categories: | Purinergics P2 receptor | | Mol File: | 389142-38-5.mol |  |
| | NF449 Chemical Properties |
| Melting point | >300°C | | density | 1.991±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | H2O: soluble | | form | solid | | pka | -2.03±0.50(Predicted) | | color | white | | Stability: | Hygroscopic |
| | NF449 Usage And Synthesis |
| Uses | NF449 is a known P2X1 receptor antagonist used to regulate the intravascular platelet aggregation commonly seen in systematic thromboembolism. | | Biological Activity | Potent purinergic receptor antagonist that displays high selectivity for P2X 1 (IC 50 values are 0.28, 0.69, 120, 1820, 47000 and > 300000 nM for rP2X 1 , rP2X 1+5 , rP2X 2+3 , rP2X 3 , rP2X 2 and P2X 4 receptors respectively). Provides antithrombotic protection in vivo . Also acts as a G s α -selective antagonist. | | in vivo | At a dose of 10 mg/kg, NF449 inhibits the ex vivo aggregation triggered by 5 g/ml collagen in WT mouse platelets without affecting that induced by 5 μM ADP. At a higher dose (50 mg/kg), NF449 inhibits ex vivo platelet aggregation in response to not only 10 g/ml collagen but also 5 M ADP, indicating nonselective inhibition of the P2Y1 and/or P2Y12 receptor[3]. | | IC 50 | p2x1 Receptor |
| | NF449 Preparation Products And Raw materials |
|